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      Postmortem Distribution of Tramadol, Amitriptyline, and Their Metabolites in a Suicidal Overdose

      , , , ,

      Journal of Analytical Toxicology

      Oxford University Press (OUP)

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          Abstract

          A case report involving a 34-year-old white male who was found dead at home by his roommate is presented. At the time of his death, he was being treated with tramadol/acetaminophen, metaxalone, oxycodone, and amitriptyline. The decedent's mother stated that he had been taking increasing amounts of pain medication in order to sleep at night. There were no significant findings at autopsy; however, toxicology results supported a cause and manner of death resulting from suicidal mixed tramadol and amitriptyline toxicity. This case reports the tissue and fluid distribution of tramadol, amitriptyline, and their metabolites in an acutely fatal ingestion in an effort to document concentrations of these analytes in 12 matrices with respect to one another to assist toxicologists in difficult interpretations.

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          Author and article information

          Journal
          Journal of Analytical Toxicology
          Journal of Analytical Toxicology
          Oxford University Press (OUP)
          0146-4760
          1945-2403
          July 01 2005
          July 01 2005
          : 29
          : 5
          : 401-406
          Article
          10.1093/jat/29.5.401
          16105270
          © 2005

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