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      The Advancing of Zinc Oxide Nanoparticles for Biomedical Applications

      review-article
      1 , 1 , 1 , 2 ,
      Bioinorganic Chemistry and Applications
      Hindawi

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          Abstract

          Zinc oxide nanoparticles (ZnO NPs) are used in an increasing number of industrial products such as rubber, paint, coating, and cosmetics. In the past two decades, ZnO NPs have become one of the most popular metal oxide nanoparticles in biological applications due to their excellent biocompatibility, economic, and low toxicity. ZnO NPs have emerged a promising potential in biomedicine, especially in the fields of anticancer and antibacterial fields, which are involved with their potent ability to trigger excess reactive oxygen species (ROS) production, release zinc ions, and induce cell apoptosis. In addition, zinc is well known to keep the structural integrity of insulin. So, ZnO NPs also have been effectively developed for antidiabetic treatment. Moreover, ZnO NPs show excellent luminescent properties and have turned them into one of the main candidates for bioimaging. Here, we summarize the synthesis and recent advances of ZnO NPs in the biomedical fields, which will be helpful for facilitating their future research progress and focusing on biomedical fields.

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          Most cited references119

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          Atopic dermatitis: a disease of altered skin barrier and immune dysregulation.

          Atopic dermatitis (AD) is an important chronic or relapsing inflammatory skin disease that often precedes asthma and allergic disorders. New insights into the genetics and pathophysiology of AD point to an important role of structural abnormalities in the epidermis as well as immune dysregulation not only for this skin disease but also for the development of asthma and allergies. Patients with AD have a unique predisposition to colonization or infection by microbial organisms, most notably Staphylococcus aureus and herpes simplex virus. Measures directed at healing and protecting the skin barrier and addressing the immune dysregulation are essential in the treatment of patients with AD, and early intervention may improve outcomes for both the skin disease as well as other target organs. © 2011 John Wiley & Sons A/S.
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            Chronic inflammation: importance of NOD2 and NALP3 in interleukin-1beta generation.

            Inflammation is part of the non-specific immune response that occurs in reaction to any type of bodily injury. In some disorders, the inflammatory process - which under normal conditions is self-limiting - becomes continuous and chronic inflammatory diseases might develop subsequently. Pattern recognition molecules (PRMs) represent a diverse collection of molecules responsible for sensing danger signals, and together with other immune components they are involved in the first line of defence. NALP3 and NOD2, which belong to a cytosolic subgroup of PRMs, dubbed Nod-like-receptors (NLRs), have been associated recently with inflammatory diseases, specifically Crohn's disease and Blau syndrome (NOD2) and familial cold autoinflammatory syndrome, Muckle-Wells syndrome and chronic infantile neurological cutaneous and articular syndrome (NALP3). The exact effects of the defective proteins are not fully understood, but activation of nuclear factor (NF)-kappaB, transcription, production and secretion of interleukin (IL)-1beta and activation of the inflammasome are some of the processes that might hold clues, and the present review will provide a thorough update in this area.
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              Zinc oxide nanoparticles: a promising nanomaterial for biomedical applications.

              Zinc oxide (ZnO) nanoparticles (NPs) are a promising platform for use in biomedical research, especially given their anticancer and antimicrobial activities. These activities are associated with the ability of ZnO NPs to generate reactive oxygen species (ROS) and induce apoptosis. In addition, ZnO NPs have been successfully exploited as drug carriers for loading and transporting drugs to target sites, thereby reducing unwanted toxicity and off-target effects, and resulting in amplified synergistic effects. Here, we discuss the synthesis and biomedical applications of ZnO NPs.
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                Author and article information

                Contributors
                Journal
                Bioinorg Chem Appl
                Bioinorg Chem Appl
                BCA
                Bioinorganic Chemistry and Applications
                Hindawi
                1565-3633
                1687-479X
                2018
                5 July 2018
                : 2018
                : 1062562
                Affiliations
                1State Key Laboratory of Quality Research in Chinese Medicines, Macau University of Science and Technology, Macau, China
                2Department of Chemistry, Jinan University, Guangzhou, China
                Author notes

                Academic Editor: Francesco Paolo Fanizzi

                Author information
                http://orcid.org/0000-0001-9869-7472
                Article
                10.1155/2018/1062562
                6057429
                30073019
                585f2d69-3108-45e8-a38f-ef4006ea8339
                Copyright © 2018 Jinhuan Jiang et al.

                This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                : 4 February 2018
                : 13 May 2018
                : 21 May 2018
                Funding
                Funded by: Science and Technology Development Fund
                Award ID: 028/2014/A1
                Funded by: China Postdoctoral Science Foundation
                Award ID: 2018M631026
                Categories
                Review Article

                Biochemistry
                Biochemistry

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