Association Between Plasma Uric Acid Levels and Cardiorenal Function in Adolescents With Type 1 Diabetes.

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Abstract

The relationship between plasma uric acid (PUA) and renal and cardiovascular parameters in adolescents with type 1 diabetes (T1D) is not well understood. Our aims in this exploratory analysis were to study the association between PUA and estimated glomerular filtration rate (eGFR), urinary albumin-to-creatinine ratio (ACR), blood pressure, endothelial function, and arterial stiffness in T1D adolescents. These associations were also studied in healthy control (HC) subjects.

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Journal

Journal ID (iso-abbrev): Diabetes Care

Title: Diabetes care

Publisher: American Diabetes Association

ISSN (Electronic): 1935-5548

ISSN (Print): 0149-5992

Publication date (Electronic): April 2016

Volume: 39

Issue: 4

Affiliations

[1 ] Department of Pharmacology and Toxicology, University of Toronto, Toronto, Canada Division of Nephrology, Department of Medicine, The University Health Network, University of Toronto, Toronto, Canada.

[2 ] Division of Endocrinology, Department of Paediatrics and JDRF Canadian Clinical Trial Network SickKids Multicenter Clinical Trial Center, The Hospital for Sick Children, University of Toronto, Toronto, Canada.

[3 ] Department of Pediatrics, University of Cambridge, Cambridge, U.K.

[4 ] University College Hospital, London, U.K.

[5 ] WellChild Laboratory, Evelina London Children's Hospital, St Thomas' Hospital, London, U.K.

[6 ] Division of Nephrology, Department of Medicine, The University Health Network, University of Toronto, Toronto, Canada.

[7 ] Division of Cardiology, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Canada.

[8 ] Department of Family & Community Medicine, University of Toronto, Toronto, Canada.

[9 ] Division of Nephrology, Department of Medicine, The University Health Network, University of Toronto, Toronto, Canada david.cherney@uhn.ca.

Article

Publisher Item ID: dc15-2345

DOI: 10.2337/dc15-2345

PubMed ID: 26895883

SO-VID: 5865ccd1-eabf-4eb5-9024-c39221aa3aeb

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