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      Antipyretic and antibacterial activity of Chloranthus erectus (Buch.-Ham.) Verdcourt leaf extract: A popular folk medicine of Arunachal Pradesh

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          Abstract

          Objective:

          The main objective of this work was to study the antipyretic and antibacterial activity of C. erectus (Buch.-Ham.) Verdcourt leaf extract in an experimental albino rat model.

          Materials and Methods:

          The methanol extract of C. erectus leaf (MECEL) was evaluated for its antipyretic potential on normal body temperature and Brewer’s yeast-induced pyrexia in albino rat’s model. While the antibacterial activity of MECEL against five Gram (−) and three Gram (+) bacterial strains and antimycotic activity was investigated against four fungi using agar disk diffusion and microdilution methods.

          Result

          Yeast suspension (10 mL/kg b.w.) elevated rectal temperature after 19 h of subcutaneous injection. Oral administration of MECEL at 100 and 200 mg/kg b.w. showed significant reduction of normal rectal body temperature and yeast-provoked elevated temperature (38.8 ± 0.2 and 37.6 ± 0.4, respectively, at 2–3 h) in a dose-dependent manner, and the effect was comparable to that of the standard antipyretic drug–paracetamol (150 mg/kg b.w.). MECEL at 2 mg/disk showed broad spectrum of growth inhibition activity against both groups of bacteria. However, MECEL was not effective against the yeast strains tested in this study.

          Conclusion

          This study revealed that the methanol extract of C. erectus exhibited significant antipyretic activity in the tested models and antibacterial activity as well, and may provide the scientific rationale for its popular use as antipyretic agent in Khamptis’s folk medicines.

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          Most cited references18

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          The Pharmacological Basis of Therapeutics

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            The Pharmacological Basis of Therapeutics

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              Screening methods in pharmacology

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                Author and article information

                Journal
                Indian J Pharmacol
                IJPharm
                Indian Journal of Pharmacology
                Medknow Publications (India )
                0253-7613
                1998-3751
                October 2010
                : 42
                : 5
                : 273-276
                Affiliations
                Pharmacognosy Research Laboratory, Department of Botany, Rajiv Gandhi University, Rono Hills, Itanagar - 7911 13, Arunachal Pradesh, India
                [1 ]Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore - 560 012 India
                [2 ]Department of Molecular Biology and Biotechnology, Tezpur University, Tezpur - 784 028, Assam India
                [3 ]Division of Pharmacognosy, Department of Pharmaceutical Technology, Jadavpur University, Jadavpur, Kolkata - 700032, India
                Author notes
                Correspondence to: Mr. Nima D. Namsa E-mail: ndnamsa@ 123456yahoo.co.in
                Article
                IJPharm-42-273
                10.4103/0253-7613.70083
                2959207
                21206616
                587f2f98-0db0-4d1b-8a55-aafb0a96e865
                © Indian Journal of Pharmacology

                This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                : 02 February 2010
                : 17 June 2010
                : 20 July 2010
                Categories
                Research Article

                Pharmacology & Pharmaceutical medicine
                khampti tribe,chloranthus erectus,antipyretic activity

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