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      Effect of Human Chorionic Gonadotropin Administration on Pituitary and Luteal Response to Gonadotropin-Releasing Hormone

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          Abstract

          The effect of human chorionic gonadotropin (hCG) administration on the pituitary and luteal responses to acute gonadotropin-releasing hormone (GnRH) administration at the mid luteal phase (LP) were studied in 20 infertile women. Patients were divided into 2 groups. In 1 group (n = 8), hCG (5,000 IU i.m.) was injected in a single shot on day 5 of LP. Sixty hours later (day 8 of LP) blood samples were taken every 15 min for 180 min; then 25 µg GnRH were acutely administered intravenously and blood samples taken at 185, 195, 210, 225, 240, 255, 270, 285 and 300 min. In the other 12 patients the same experimental design with GnRH was performed on day 8 of an untreated LP. Plasma LH, FSH, β-hCG, progesterone and estradiol (E<sub>2</sub>) were assayed. The responsiveness of different hormones to GnRH was evaluated as integrated secretory area for 120 min after injection (sISA) and as the absolute increase with respect to the area under basal conditions before a GnRH administration (bISA). hCG-treated patients showed higher basal and bISA plasma values of LH/hCG than controls (p < 0.01). After GnRH the amplitude of LH secretion was similar in both groups. Also bISA and sISA values of FSH were similar in both groups. Basal and bISA plasma values of progesterone and E<sub>2</sub> secretion were similar in hCG-treated and control patients. After GnRH administration a significant increase in progesterone (p < 0.01) and E<sub>2</sub> (p < 0.05) secretion was seen in controls, while this response failed in hCG-treated patients, so that the amplitude of progesterone secretion was significantly greater in controls than in hCG-treated patients (p < 0.01). The results of this study suggest that hCG administration leads to a dissociation of corpus luteum secretion from hypothalamic-pituitary axis, probably due to a transitory exhaustion of corpus luteum steroidogenesis in respect to endogenous gonadotropin stimuli.

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          Author and article information

          Journal
          HRE
          Horm Res Paediatr
          10.1159/issn.1663-2818
          Hormone Research in Paediatrics
          S. Karger AG
          1663-2818
          1663-2826
          1989
          1989
          02 December 2008
          : 32
          : 5-6
          : 203-207
          Affiliations
          Department of Obstetrics and Gynecology, Università Cattolica del Sacro Cuore, Rome, Italy
          Article
          181290 Horm Res 1989;32:203–207
          10.1159/000181290
          2483932
          © 1989 S. Karger AG, Basel

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          Page count
          Pages: 5
          Categories
          Original Paper

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