+1 Recommend
1 collections
      • Record: found
      • Abstract: found
      • Article: found

      Effect of Human Chorionic Gonadotropin Administration on Pituitary and Luteal Response to Gonadotropin-Releasing Hormone

      Read this article at

          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.


          The effect of human chorionic gonadotropin (hCG) administration on the pituitary and luteal responses to acute gonadotropin-releasing hormone (GnRH) administration at the mid luteal phase (LP) were studied in 20 infertile women. Patients were divided into 2 groups. In 1 group (n = 8), hCG (5,000 IU i.m.) was injected in a single shot on day 5 of LP. Sixty hours later (day 8 of LP) blood samples were taken every 15 min for 180 min; then 25 µg GnRH were acutely administered intravenously and blood samples taken at 185, 195, 210, 225, 240, 255, 270, 285 and 300 min. In the other 12 patients the same experimental design with GnRH was performed on day 8 of an untreated LP. Plasma LH, FSH, β-hCG, progesterone and estradiol (E<sub>2</sub>) were assayed. The responsiveness of different hormones to GnRH was evaluated as integrated secretory area for 120 min after injection (sISA) and as the absolute increase with respect to the area under basal conditions before a GnRH administration (bISA). hCG-treated patients showed higher basal and bISA plasma values of LH/hCG than controls (p < 0.01). After GnRH the amplitude of LH secretion was similar in both groups. Also bISA and sISA values of FSH were similar in both groups. Basal and bISA plasma values of progesterone and E<sub>2</sub> secretion were similar in hCG-treated and control patients. After GnRH administration a significant increase in progesterone (p < 0.01) and E<sub>2</sub> (p < 0.05) secretion was seen in controls, while this response failed in hCG-treated patients, so that the amplitude of progesterone secretion was significantly greater in controls than in hCG-treated patients (p < 0.01). The results of this study suggest that hCG administration leads to a dissociation of corpus luteum secretion from hypothalamic-pituitary axis, probably due to a transitory exhaustion of corpus luteum steroidogenesis in respect to endogenous gonadotropin stimuli.

          Related collections

          Author and article information

          Horm Res Paediatr
          Hormone Research in Paediatrics
          S. Karger AG
          02 December 2008
          : 32
          : 5-6
          : 203-207
          Department of Obstetrics and Gynecology, Università Cattolica del Sacro Cuore, Rome, Italy
          181290 Horm Res 1989;32:203–207
          © 1989 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 5
          Original Paper


          Comment on this article