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      Tumor metastasis: molecular insights and evolving paradigms.

      1 ,
      Cell
      Elsevier BV

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          Abstract

          Metastases represent the end products of a multistep cell-biological process termed the invasion-metastasis cascade, which involves dissemination of cancer cells to anatomically distant organ sites and their subsequent adaptation to foreign tissue microenvironments. Each of these events is driven by the acquisition of genetic and/or epigenetic alterations within tumor cells and the co-option of nonneoplastic stromal cells, which together endow incipient metastatic cells with traits needed to generate macroscopic metastases. Recent advances provide provocative insights into these cell-biological and molecular changes, which have implications regarding the steps of the invasion-metastasis cascade that appear amenable to therapeutic targeting.

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          Author and article information

          Journal
          Cell
          Cell
          Elsevier BV
          1097-4172
          0092-8674
          Oct 14 2011
          : 147
          : 2
          Affiliations
          [1 ] Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA. scott_valastyan@hms.harvard.edu
          Article
          NIHMS329992 S0092-8674(11)01085-3
          10.1016/j.cell.2011.09.024
          3261217
          22000009
          58afb321-46a7-43bc-a4b7-9b8fabbdadb1
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