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      Ultrasonography Diagnosis and Imaging-Based Management of Thyroid Nodules: Revised Korean Society of Thyroid Radiology Consensus Statement and Recommendations

      review-article
      , MD 1 , , MD 2 , , MD 3 , , MD 4 , , MD 5 , , MD 6 , , MD 7 , , MD 8 , , MD, PhD 9 , , , MD 10 , , MD 11 , , MD 1 , , MD 12 , , MD 13 , , MD 14 , , MD 15 , , MD 15 , , MD 16 , , MD 17 , , MD 2 , , MD 18 , , MD 19 , , MD 20 , , MD 21 , Korean Society of Thyroid Radiology (KSThR) and Korean Society of Radiology
      Korean Journal of Radiology
      The Korean Society of Radiology
      Thyroid nodule, Thyroid neoplasm, Lymph nodes, Ultrasonography, Multidetector computed tomography, Ablation techniques

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          Abstract

          The rate of detection of thyroid nodules and carcinomas has increased with the widespread use of ultrasonography (US), which is the mainstay for the detection and risk stratification of thyroid nodules as well as for providing guidance for their biopsy and nonsurgical treatment. The Korean Society of Thyroid Radiology (KSThR) published their first recommendations for the US-based diagnosis and management of thyroid nodules in 2011. These recommendations have been used as the standard guidelines for the past several years in Korea. Lately, the application of US has been further emphasized for the personalized management of patients with thyroid nodules. The Task Force on Thyroid Nodules of the KSThR has revised the recommendations for the ultrasound diagnosis and imaging-based management of thyroid nodules. The review and recommendations in this report have been based on a comprehensive analysis of the current literature and the consensus of experts.

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          Most cited references174

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          The Bethesda System for Reporting Thyroid Cytopathology: a meta-analysis.

          We aimed to investigate the validity of the Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) through meta-analysis. All publications between January 1, 2008 and September 1, 2011 that studied TBSRTC and had available histological follow-up data were retrieved. To calculate the sensitivity, specificity and diagnostic accuracy, the cases diagnosed as follicular neoplasm, suspicious for malignancy and malignant which were histopathologically confirmed as malignant were defined as true-positive. True-negative included benign cases confirmed as benign on histopathology. The nondiagnostic category was excluded from the statistical calculation. The correlations between the 6 diagnostic categories were investigated. The publications review resulted in a case cohort of 25,445 thyroid fine-needle aspirations, 6,362 (25%) of which underwent surgical excision; this group constituted the basis of the study. The sensitivity, specificity and diagnostic accuracy were 97, 50.7 and 68.8%, respectively. The positive predictive value and negative predictive value were 55.9 and 96.3%, respectively. The rates of false negatives and false positives were low: 3 and 0.5%, respectively. The results of meta-analysis showed high overall accuracy, indicating that TBSRTC represents a reliable and valid reporting system for thyroid cytology. Copyright © 2012 S. Karger AG, Basel.
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            Patient age is significantly related to the progression of papillary microcarcinoma of the thyroid under observation.

            We showed previously that subclinical low-risk papillary thyroid microcarcinoma (PTMC) could be observed without immediate surgery. Patient age is an important prognostic factor of clinical papillary thyroid carcinoma (PTC). In this study, we investigated how patient age influences the observation of low-risk PTMC.
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              An observational trial for papillary thyroid microcarcinoma in Japanese patients.

              The recent development and spread of ultrasonography and ultrasonography-guided fine needle aspiration biopsy (FNAB) has facilitated the detection of small papillary microcarcinomas of the thyroid measuring 1 cm or less (PMC). The marked difference in prevalence between clinical thyroid carcinoma and PMC detected on mass screening prompted us to observe PMC unless the lesion shows unfavorable features, such as location adjacent to the trachea or on the dorsal surface of the thyroid possibly invading the recurrent laryngeal nerve, clinically apparent nodal metastasis, or high-grade malignancy on FNAB findings. In the present study we report comparison of the outcomes of 340 patients with PMC who underwent observation and the prognosis of 1,055 patients who underwent immediate surgery without observation. Between 1993 and 2004, 340 patients underwent observation and 1,055 underwent surgical treatment without observation. These 1,395 patients were enrolled in the present study. Observation periods ranged from 18 to 187 months (average 74 months). The proportions of patients whose PMC showed enlargement by 3 mm or more were 6.4 and 15.9% on 5-year and 10-year follow-up, respectively. Novel nodal metastasis was detected in 1.4% at 5 years and 3.4% at 10 years. There were no factors related to patient background or clinical features linked to either tumor enlargement or the novel appearance of nodal metastasis. After observation 109 of the 340 patients underwent surgical treatment for various reasons, and none of those patients showed carcinoma recurrence. In patients who underwent immediate surgical treatment, clinically apparent lateral node metastasis (N1b) and male gender were recognized as independent prognostic factors of disease-free survival. Papillary microcarcinomas that are not associated with unfavorable features can be candidates for observation regardless of patient background and clinical features. If there are subsequent signs of progression, such as tumor enlargement and novel nodal metastasis, it would not be too late to perform surgical treatment. Even though the primary tumor is small, careful surgical treatment including therapeutic modified neck dissection is necessary for N1b PMC patients.
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                Author and article information

                Journal
                Korean J Radiol
                Korean J Radiol
                KJR
                Korean Journal of Radiology
                The Korean Society of Radiology
                1229-6929
                2005-8330
                May-Jun 2016
                14 April 2016
                : 17
                : 3
                : 370-395
                Affiliations
                [1 ]Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Korea.
                [2 ]Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul 05505, Korea.
                [3 ]Department of Radiology, Ewha Womans University School of Medicine, Seoul 07985, Korea.
                [4 ]Department of Radiology, Ajou University School of Medicine, Suwon 16499, Korea.
                [5 ]Department of Radiology, Seoul National University College of Medicine, Seoul 03080, Korea.
                [6 ]Department of Radiology, Ansan Hospital, Korea University College of Medicine, Ansan 15355, Korea.
                [7 ]Department of Radiology, Soonchunhyang University Seoul Hospital, Seoul 04401, Korea.
                [8 ]Department of Radiology, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul 05030, Korea.
                [9 ]Department of Radiology, Human Medical Imaging and Intervention Center, Seoul 06524, Korea.
                [10 ]Department of Radiology, Hanyang University College of Medicine, Hanyang University Hospital, Seoul 04763, Korea.
                [11 ]Department of Radiology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul 03181, Korea.
                [12 ]Department of Radiology, Wonkwang University Hospital, Iksan 54538, Korea.
                [13 ]Department of Radiology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.
                [14 ]Department of Radiology, Busan Paik Hospital, Inje University College of Medicine, Busan 47392, Korea.
                [15 ]Department of Radiology, Severance Hospital, Research Institute of Radiological Science, Yonsei University College of Medicine, Seoul 03722, Korea.
                [16 ]Department of Radiology, Research Institute and Hospital, National Cancer Center, Goyang 10408, Korea.
                [17 ]Department of Radiology, Kyungpook National University Hospital, Daegu 41944, Korea.
                [18 ]Department of Radiology, Dong-A University Medical Center, Busan 49201, Korea.
                [19 ]Department of Radiology, Newwoori Namsan Hospital, Busan 46224, Korea.
                [20 ]Department of Radiology, SMG-SNU Boramae Medical Center, Seoul National University College of Medicine, Seoul 07061, Korea.
                [21 ]Department of Radiology and Thyroid Center, Daerim St. Mary's Hospital, Seoul 07442, Korea.
                Author notes
                Corresponding author: Dong Gyu Na, MD, PhD, Department of Radiology, Human Medical Imaging and Intervention Center, 621 Gangnam-daero, Seocho-gu, Seoul 06524, Korea. Tel: (822) 512-6695, Fax: (822) 512-6646, nndgna@ 123456gmail.com
                Article
                10.3348/kjr.2016.17.3.370
                4842857
                27134526
                58b23d0d-eb14-45c7-8702-7baa44d4c03f
                Copyright © 2016 The Korean Society of Radiology

                This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                : 15 January 2016
                : 22 January 2016
                Funding
                Funded by: Korean Society of Radiology;
                Categories
                Thyroid
                Review Article

                Radiology & Imaging
                thyroid nodule,thyroid neoplasm,lymph nodes,ultrasonography,multidetector computed tomography,ablation techniques

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