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      Leukotriene B4 receptor BLT1 mediates early effector T cell recruitment.

      Nature immunology

      Animals, Asthma, immunology, Bronchoalveolar Lavage Fluid, cytology, CD4-Positive T-Lymphocytes, Chemotaxis, Leukocyte, Disease Models, Animal, Female, Flow Cytometry, Immunoglobulin E, Immunoglobulin G, Leukotriene B4, Lymphocyte Activation, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Receptors, Leukotriene B4, T-Lymphocyte Subsets

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          Abstract

          Leukotriene B4 (LTB4) was originally described as a potent lipid myeloid cell chemoattractant, rapidly generated from innate immune cells, that activates leukocytes through the G protein-coupled receptor BLT1. We report here that BLT1 is expressed on effector CD4+ T cells generated in vitro as well as in vivo when effector T cells migrate out of the lymphoid compartment and are recruited into peripheral tissues. BLT1 mediated LTB4-induced T helper type 1 (T(H)1) and T(H)2 cell chemotaxis and firm adhesion to endothelial cells under flow, as well as early CD4+ and CD8+ T cell recruitment into the airway in an asthma model. Our findings show that the LTB4-BLT1 pathway is involved in linking early immune system activation and early effector T cell recruitment.

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          Journal
          12949531
          10.1038/ni970

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