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      Parecoxib mitigates spatial memory impairment induced by sevoflurane anesthesia in aged rats.

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          Abstract

          Inflammation in brain plays a critical role in the pathogenesis of cognitive impairment. Anti-inflammatory therapy may thus constitute a novel approach for associated cognitive dysfunction. The present study investigated the effects of parecoxib in the prevention of cognitive impairments induced by sevoflurane in aged rats.

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          Author and article information

          Journal
          Acta Anaesthesiol Scand
          Acta anaesthesiologica Scandinavica
          1399-6576
          0001-5172
          May 2012
          : 56
          : 5
          Affiliations
          [1 ] Department of Anesthesiology, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
          Article
          10.1111/j.1399-6576.2012.02665.x
          22409586
          © 2012 The Authors. Acta Anaesthesiologica Scandinavica © 2012 The Acta Anaesthesiologica Scandinavica Foundation.

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