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High plasma erythropoietin levels are associated with prolonged coma duration and increased mortality in children with cerebral malaria.
Estela Shabani
1 ,
Robert O Opoka
2 ,
Richard Idro
2 ,
Robert Schmidt
3 ,
Gregory S Park
1 ,
Paul Bangirana
2 ,
Gregory M Vercellotti
1 ,
James S Hodges
1 ,
John A Widness
3 ,
Chandy C John
1
Jan 1 2015
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Abstract
Elevated endogenous plasma erythropoietin (EPO) levels have been associated with protection from acute neurologic deficits in Kenyan children with cerebral malaria (CM). Based on these findings and animal studies, clinical trials of recombinant human EPO (rHuEPO) have been started in children with CM. Recent clinical trials in adults with acute ischemic stroke have demonstrated increased mortality with rHuEPO treatment. We conducted a study in children with CM to assess the relationship of endogenous plasma and cerebrospinal fluid (CSF) EPO levels with mortality and acute and long-term neurologic outcomes.