+1 Recommend
1 collections
      • Record: found
      • Abstract: found
      • Article: found

      Changes in Vascular Distensibility during Angiotensin-Converting Enzyme Inhibition Involve Bradykinin Type 2 Receptors

      Read this article at

          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.


          Changes in arterial stiffness and structure occur during cardiovascular diseases and can be modified by angiotensin-converting enzyme (ACE) inhibitors. In the present study we investigated the role of membrane-bound ACE (t-ACE) in the regulation of arterial structure and mechanics. Large and small arteries of t-ACE–/– mice were isolated to determine the passive pressure-diameter relationship. We observed that t-ACE–/– mice exhibit a reduced arterial distensibility compared to t-ACE+/+ mice. This reduced arterial distensibility was also observed after 9 weeks of captopril treatment (80 mg/kg/ day). We hypothesized that bradykinin type 2 receptor (BK<sub>2</sub>) stimulation might be involved in the regulation of arterial stiffness. t-ACE–/– and t-ACE+/+ mice were treated with Hoe 140 (1 mg/kg/day) for 14 days. After Hoe 140 treatment, both the structural and mechanical changes observed in the t-ACE–/– carotid artery were abolished. Although Hoe 140 administration increased blood pressure in both groups by approximately 10 mm Hg, the pressure difference between the two groups did not change. Thus, t-ACE is involved in the regulation of arterial distensibility. The changes observed in t-ACE–/– mice are not caused by an altered fetal development. Moreover, it is likely that the regulation of arterial distensibility by ACE involves stimulation of the BK<sub>2</sub> receptor.

          Related collections

          Most cited references 5

          • Record: found
          • Abstract: not found
          • Article: not found

          Cerebral Arteriolar Structure in Mice Overexpressing Human Renin and Angiotensinogen

            • Record: found
            • Abstract: not found
            • Article: not found

            Pressure but not angiotensin II-induced increases in wall mass or tone influences static and dynamic aortic mechanics

              • Record: found
              • Abstract: not found
              • Article: not found

              Enalapril Improves Arterial Elastic Properties in Rats with Myocardial Infarction


                Author and article information

                J Vasc Res
                Journal of Vascular Research
                S. Karger AG
                February 2004
                20 February 2004
                : 41
                : 1
                : 18-27
                Departments of aPharmacology and Toxicology and bPathology, Cardiovascular Research Institute Maastricht, University of Maastricht, Maastricht, The Netherlands
                76125 J Vasc Res 2004;41:18–27
                © 2004 S. Karger AG, Basel

                Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

                Page count
                Figures: 4, Tables: 2, References: 33, Pages: 10
                Research Paper


                Comment on this article