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      Sequence analysis of the Ras-MAPK pathway genes SOS1, EGFR & GRB2 in silver foxes (Vulpes vulpes): candidate genes for hereditary hyperplastic gingivitis.

      1 , ,
      Genetica
      Springer Science and Business Media LLC

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          Abstract

          Hereditary hyperplastic gingivitis (HHG) is an autosomal recessive disease that presents with progressive gingival proliferation in farmed silver foxes. Hereditary gingival fibromatosis (HGF) is an analogous condition in humans that is genetically heterogeneous with several known autosomal dominant loci. For one locus the causative mutation is in the Son of sevenless homologue 1 (SOS1) gene. For the remaining loci, the molecular mechanisms are unknown but Ras pathway involvement is suspected. Here we compare sequences for the SOS1 gene, and two adjacent genes in the Ras pathway, growth receptor bound protein 2 (GRB2) and epidermal growth factor receptor (EGFR), between HHG-affected and unaffected foxes. We conclude that the known HGF causative mutation does not cause HHG in foxes, nor do the coding regions or intron-exon boundaries of these three genes contain any candidate mutations for fox gum disease. Patterns of molecular evolution among foxes and other mammals reflect high conservation and strong functional constraints for SOS1 and GRB2 but reveal a lineage-specific pattern of variability in EGFR consistent with mutational rate differences, relaxed functional constraints, and possibly positive selection.

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          Author and article information

          Journal
          Genetica
          Genetica
          Springer Science and Business Media LLC
          1573-6857
          0016-6707
          Dec 2014
          : 142
          : 6
          Affiliations
          [1 ] Department of Biology, Memorial University of Newfoundland, St. John's NL, A1B 3X9, Canada, j.clark@mun.ca.
          Article
          10.1007/s10709-014-9798-x
          25377643
          58fc069e-4577-47c2-b943-33ae53170c86
          History

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