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      Impulse oscillometry in preschool children with persistent asthma can predict spirometry at school age

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          Abstract

          Background

          Lung function in children with persistent asthma may be impaired during preschool and school ages. The aim of this study was to describe if some preschool impulse oscillometry (IOS) parameters are related to spirometry alterations on reaching school age.

          Methods

          In 66 diagnosed with persistent asthma, an IOS was performed at entrance and followed‐up to school age where a spirometry was done.

          Results

          The mean age was 4.9 years at the first evaluation and 7.9 years at the second evaluation, and 59.1% were male. During preschool, R5, R20, Fres, AX, and D5−20 were found to have diagnostic accuracy (area under the curve > 0.7) for predicting abnormal spirometry during school age (defined as FEV1 and/or FEV/FVC and/or FVC values below the lower limit of normality according to Quanjer predictive values). AX, D5−20, and R5 had the best LR+ to increase the probability of abnormal spirometry (50, 10, and 7.1, respectively). R20, R5, and AX was the best IOS parameters for discriminating bronchodilator response (BDR) in schoolchildren (LR+ = 3.4, 2.9, and 2.8, respectively).

          Conclusion

          The findings of this study indicate that some IOS parameters between 3 and 5 years of age are useful for predicting abnormal spirometry and BDR at school age.

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          Author and article information

          Contributors
          (View ORCID Profile)
          Journal
          Pediatric Pulmonology
          Pediatric Pulmonology
          Wiley
          8755-6863
          1099-0496
          May 2023
          February 07 2023
          May 2023
          : 58
          : 5
          : 1411-1416
          Affiliations
          [1 ] Department of Pediatric Pulmonology Clínica Las Condes Santiago Chile
          [2 ] Department of Pediatric Pulmonology, School of Medicine Pontificia Universidad Católica de Chile Santiago Chile
          Article
          10.1002/ppul.26333
          36704870
          5907ce90-c178-4046-9045-f2064fc4e62c
          © 2023

          http://onlinelibrary.wiley.com/termsAndConditions#vor

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