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      Benzophenone-3: rapid prediction and evaluation using non-invasive methods of in vivo human penetration

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      Journal of Pharmaceutical and Biomedical Analysis

      Elsevier BV

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          Abstract

          The study described in this paper constitutes a practical assay system to evaluate in vivo drug penetration using two complementary non-invasive methods. An electrical capacitance test was first applied to the skin on the forearm to evaluate the hydration of the skin, and check the integrity of the stratum corneum. In the first step, the percentage absorption was measured using an occlusive and difference method; following benzophenone-3 application any residual formulation was washed off and the amount removed analyzed. In the second step, the tape stripping method-a useful procedure for selectively removing the skin's outermost layer, the stratum corneum, and measuring the stratum corneum adsorption-was performed. Under these conditions the human skin permeation of this UV-filter over four hours was near to 35% of the applied dose with the occlusive method. The amount of topically applied benzophenone-3 found in the stratum corneum after 30 min exposure using the stripping procedure was evaluated at 4% to the applied dose.

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          Author and article information

          Journal
          Journal of Pharmaceutical and Biomedical Analysis
          Journal of Pharmaceutical and Biomedical Analysis
          Elsevier BV
          07317085
          April 2002
          April 2002
          : 28
          : 1
          : 57-63
          Article
          11861108
          © 2002

          https://www.elsevier.com/tdm/userlicense/1.0/

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