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      Sedative and antinociceptive activities of two new sesquiterpenes isolated from Ricinus communis

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          Abstract

          Two new sesquiterpenes, trivially named ricinusoids A ( 1) and ricinusoids B ( 2), were isolated from ethyl acetate fraction of Ricinus communis. The structures of new compounds were elucidated by detailed spectroscopic techniques, including 1D- and 2D-NMR, UV, IR spectroscopy, and mass spectrometry. The compounds ( 1–2) were also assessed for in-vivo sedative and analgesic like effects in open field and acetic acid induced writhing tests respectively at 5, 10, and 20 mg·kg −1 i.p. Pretreatment of both test compounds caused significant ( P ≤ 0.05) reduction in locomotive activity like sedative agents and abdominal constrictions like analgesics. Both compounds ( 1–2) possessed marked sedative and antinociceptive effects in animal models.

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          Author and article information

          Journal
          CJNM
          Chinese Journal of Natural Medicines
          Elsevier
          1875-5364
          20 March 2018
          : 16
          : 3
          : 225-230
          Affiliations
          1Department of Chemistry, COMSATS Institute of Information Technology, Abbottabad 22060, Pakistan
          2UoN Chair of Oman's Medicinal Plants and Marine Natural Products, University of Nizwa, Nizwa 616, Sultanate of Oman
          3Department of Geology, University of Swabi Anbar, Khyber Pakhtunkhwa 23430, Pakistan
          4Department of Pharmacy, Abdul Wali Khan University, Mardan 23200, Pakistan
          5Department of Pharmacy, Abasyn University, Peshawar 25000, Pakistan
          Author notes
          *Corresponding authors: Umar Farooq, Tel: +6(0)391459567, Fax: +6(0)291459547, E-mails: umarf@ 123456ciit.net.pk ; Ajmal Khan, ajmalkhan@ 123456ciit.net.pk ; Afsar Khan, afsarkhan@ 123456ciit.net.pk

          These authors have no conflict of interest to declare.

          Article
          S1875-5364(18)30051-7
          10.1016/S1875-5364(18)30051-7
          Copyright © 2018 China Pharmaceutical University. Published by Elsevier B.V. All rights reserved.
          Funding
          Funded by: Higher Education Commission of Pakistan
          Award ID: 2003
          This work was financially supported by the Higher Education Commission of Pakistan (No. 2003).

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