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      Drug delivery by supramolecular design

      Author(s): ,
      Publication date (Print):
      Journal: Chem. Soc. Rev.
      Publisher: Royal Society of Chemistry (RSC)

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          Abstract

          Principles rooted in supramolecular chemistry have empowered new and highly functional therapeutics and drug delivery devices. This general approach offers elegant tools rooted in molecular and materials engineered to address the many challenges faced in treating disease.

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          Mechanisms of solute release from porous hydrophilic polymers

          Richard W. Korsmeyer, Robert Gurny, Eric Doelker … (1983)
          Article 0 comments Cited 637 times – based on 0 reviews     Review now
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            Supramolecular polymerization.

            Tom de Greef, Maarten Smulders, Martin Wolffs … (2009)
            Article 0 comments Cited 520 times – based on 0 reviews     Review now
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              The dawning era of polymer therapeutics.

              Ruth Duncan (2003)
              As we enter the twenty-first century, research at the interface of polymer chemistry and the biomedical sciences has given rise to the first nano-sized (5-100 nm) polymer-based pharmaceuticals, the 'polymer therapeutics'. Polymer therapeutics include rationally designed macromolecular drugs, polymer-drug and polymer-protein conjugates, polymeric micelles containing covalently bound drug, and polyplexes for DNA delivery. The successful clinical application of polymer-protein conjugates, and promising clinical results arising from trials with polymer-anticancer-drug conjugates, bode well for the future design and development of the ever more sophisticated bio-nanotechnologies that are needed to realize the full potential of the post-genomic age.
              Article 0 comments Cited 504 times – based on 0 reviews     Review now
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                Author and article information

                Journal
                Journal ID (publisher-id): CSRVBR
                Title: Chem. Soc. Rev.
                Abbreviated Title: Chem. Soc. Rev.
                Publisher: Royal Society of Chemistry (RSC)
                ISSN (Print): 0306-0012
                ISSN (Electronic): 1460-4744
                Publication date Created: 2017
                Publication date (Print): 2017
                Volume:
                Issue:
                Article
                DOI: 10.1039/C7CS00391A
                PubMed ID: 28828455
                SO-VID: 5933d06a-24d0-46ab-84a1-cace8b043bfc
                Copyright © © 2017
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