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      Beta-2-Microglobulin in Mesangial IgA Nephropathy

      , , , , ,

      Nephron

      S. Karger AG

      IgA nephritis, β2-Microglobulin, Sclerosis, Proteinuria

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          Abstract

          This study measured plasma β<sub>2</sub>-microglobulin (β<sub>2</sub>-m) in patients with mesangial IgA nephritis. Plasma β<sub>2</sub>-m was measured in 51 patients with IgA mesangial nephritis and in 50 normal controls using a Phadebas β<sub>2</sub>-m RIA kit available from Pharmacia Diagnostics (Uppsala, Sweden). The mean plasma β<sub>2</sub>-m in IgA nephritic patients (1.92 ± 0.67 mg/l) was significantly different from that of healthy controls (1.33 ± 0.41 mg/l; p < 0.001). The mean plasma β<sub>2</sub>-m in non-IgA nephritic patients (1.83 ± 0.73 mg/l) was also significantly different (p < 0.001). Patients with IgA nephritis with glomerular sclerosis (n = 33) had significantly higher levels of β<sub>2</sub>-m (2.02 ± 0.70 mg/l) than IgA nephritic patients without glomerular sclerosis (n = 18, 1.72 ± 0.65 mg/l; p < 0.025). In the group with IgA nephritis and glomerulosclerosis, raised β<sub>2</sub>-m levels were correlated with the severity of proteinuria (r = 0.41) (p < 0.02) as well as the intensity of IgA staining on immunofluorescence (r = 0.34; p < 0.05). Elevated β<sub>2</sub>-m levels in IgA nephritis may serve as a useful prognostic marker.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1984
          1984
          04 December 2008
          : 37
          : 2
          : 78-81
          Affiliations
          Department of Renal Medicine and the University Department of Medicine II, Singapore General Hospital, Singapore
          Article
          183218 Nephron 1984;37:78–81
          10.1159/000183218
          6374483
          © 1984 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 4
          Categories
          Original Paper

          Cardiovascular Medicine, Nephrology

          Proteinuria, β2-Microglobulin, Sclerosis, IgA nephritis

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