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      Chemical constituents from Vernonia bockiana

      1 , 2 , 1 , , 1

      Chinese Journal of Natural Medicines

      Elsevier BV

      Vernonia bockiana , Sesquiterpenoid, Steroid

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          Abstract

          A new sesquiterpenoid and two pregnane steroids, named vernobockolide C ( 1) and vernobockones A and B ( 2 and 3), respevtively, along with a known sesquiterpenoid, 7, 10-epoxy-11-hydroxy-bisabol-2-en-15-al, were isolated from the aerial part of Vernonia bockiana. Their structures were elucidated on the basis of extensive spectroscopic data analysis, especially 2D NMR (HSQC, HMBC, and ROESY). This study further expands the chemical space of this underexplored species.

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          Author and article information

          Journal
          CJNM
          Chinese Journal of Natural Medicines
          Elsevier BV
          1875-5364
          20 December 2019
          : 17
          : 12
          : 924-927
          Affiliations
          1 State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
          2 State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China
          Author notes
          *Corresponding author: YUE Jian-Min, Tel/Fax: 86-21-50806718, E-mail: jmyue@ 123456simm.ac.cn

          These authors have no conflict of interest to declare.

          Dedicated to Professor SUN Han-Dong on the Occasion of His 80th Birthday

          Article
          S1875-5364(19)30114-1
          10.1016/S1875-5364(19)30114-1
          Copyright © 2019 China Pharmaceutical University. Published by Elsevier B.V. All rights reserved.
          Funding
          Funded by: Drug Innovation Major Project of China
          Award ID: 2018ZX09711001-001-005
          Funded by: Biological Resources Programme
          Award ID: CAS KFJ-BRP-008
          This work was supported by the Drug Innovation Major Project of China (No. 2018ZX09711001-001-005), and the Biological Resources Programme (No. CAS KFJ-BRP-008).
          Categories
          Research article

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