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      Glutathione is the main endogenous inhibitor of protein glycation.

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          Abstract

          Glycation is the cause of diabetic complications and contributes to the development of other diseases and aging. Numerous exogenous compounds have been tested for their anti-glycating activity. The aim of this study was to answer the question, which endogenous compounds at physiological concentrations can effectively prevent glycation. A set of endogenous compounds has been tested for the ability to protect albumin from glucose-induced glycation in vitro at a concentration of 1 mM and in a physiological concentration range. Only glutathione was found to protect significantly against glycation at physiological concentrations. Glutathione depletion increased the rate of hemoglobin glycation in erythrocytes incubated with high glucose concentrations. These results indicate that the level of glutathione is the main determinant of glycation of intracellular proteins.

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          Author and article information

          Journal
          Gen. Physiol. Biophys.
          General physiology and biophysics
          AEPress, s.r.o.
          0231-5882
          0231-5882
          Apr 2017
          : 36
          : 2
          Affiliations
          [1 ] Department of Biochemistry and Cell Biology, Faculty of Biology and Agriculture, University of Rzeszów, Rzeszów, Poland. isadowska@poczta.fm.
          Article
          10.4149/gpb_2016044
          28218612
          5956ebb7-fc88-4e66-8ece-2663905dd08a
          History

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