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      Analysis of the Asymmetric Response of the Rabbit Ear Artery to Intimal and Adventitial Amines

      ,

      Journal of Vascular Research

      S. Karger AG

      Norepinephrine, Rabbit, Ear artery, Adrenoreceptors, Phenylephrine, Yohimbine, Prasozin, Clonidine

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          Abstract

          Ring segments of the rabbit ear artery were studied in the normal configuration (where drugs entered the media mainly through the adventitia) and in the everted configuration (where drugs entered mainly through the intima). Norepinephrine (NE) produced a faster response when added to the intima. This difference was not due to NE uptake mechanisms or asymmetry of different types of alpha-receptor. However, tetraethylammonium chloride (which abolishes rectification and increases membrane electrical activity) selectively increased the velocity of contraction of the normal artery segments to NE. These results suggest that approximately 50% of the difference between the intimal and adventitial velocity of contraction to NE is due to the presence of an intimal electromechanical coupling mechanism which does not operate at the adventitia. The remaining difference may be due to a closer proximity of medial alpha-receptor to the intimal surface.

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          Author and article information

          Journal
          JVR
          J Vasc Res
          10.1159/issn.1018-1172
          Journal of Vascular Research
          S. Karger AG
          1018-1172
          1423-0135
          1984
          1984
          23 September 2008
          : 21
          : 2
          : 64-71
          Affiliations
          Department of Pharmacology, University of Houston, Houston, Tex., USA
          Article
          158496 Blood Vessels 1984;21:64–71
          10.1159/000158496
          © 1984 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 8
          Categories
          Research Paper

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