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      The Effect of Guanethidine and Propranolol on Capillary Blood Flow in Subcutaneous Tissue and Muscle in Essential Hypertension

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          Abstract

          Local capillary blood flow in subcutaneous tissue and muscle was measured by tissue clearance of Na <sup>131</sup>I at rest and during vasomotor reactions in 33 patients with essential hypertension and in an age-matched control group, before and after application of guanethidine and propranolol. Capillary blood flow in the subcutaneous tissue of the hand and leg as well as in the calf musculature was significantly lower in hypertensive than in normotensive subjects, whereas capillary blood flow in forearm muscles was greater in hypertensives than in controls. Guanethidine returned the values of capillary blood flow in hypertensive patients to the values characteristic of normotensive controls before drug administration. Propranolol produced a significant decrease of capillary blood flow in subcutaneous tissue of the hand and leg, as well as in both forearm and calf muscles.

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          Author and article information

          Journal
          CRD
          Cardiology
          10.1159/issn.0008-6312
          Cardiology
          S. Karger AG
          0008-6312
          1421-9751
          1974
          1974
          29 October 2008
          : 59
          : 3
          : 172-183
          Affiliations
          Ist Medical Clinic, Faculty of Medicine, Commenius University, and Institute of Normal and Pathological Physiology, Slovak Academy of Sciences, Bratislava
          Article
          169675 Cardiology 1974;59:172–183
          10.1159/000169675
          4447953
          © 1974 S. Karger AG, Basel

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          Page count
          Pages: 12
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