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      The emergence of Lyme disease.

      The Journal of clinical investigation

      microbiology, Animals, Humans, Lyme Disease, diagnosis, etiology, therapy, Ticks

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          Abstract

          Since its identification nearly 30 years ago, Lyme disease has continued to spread, and there have been increasing numbers of cases in the northeastern and north central US. The Lyme disease agent, Borrelia burgdorferi, causes infection by migration through tissues, adhesion to host cells, and evasion of immune clearance. Both innate and adaptive immune responses, especially macrophage- and antibody-mediated killing, are required for optimal control of the infection and spirochetal eradication. Ecological conditions favorable to the disease, and the challenge of prevention, predict that Lyme disease will be a continuing public health concern.

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          Author and article information

          Journal
          15085185
          385417
          10.1172/JCI21681

          Chemistry

          microbiology, Animals, Humans, Lyme Disease, diagnosis, etiology, therapy, Ticks

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