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Shorter survival in advanced human immunodeficiency virus type 1 infection is more closely associated with T lymphocyte activation than with plasma virus burden or virus chemokine coreceptor usage.

The Journal of Infectious Diseases

immunology, T-Lymphocytes, physiology, Receptors, CXCR4, Receptors, CCR5, blood, RNA, Viral, analysis, NAD+ Nucleosidase, Middle Aged, Membrane Glycoproteins, Male, Lymphocyte Activation, Humans, HLA-DR Antigens, HIV-1, CD4 Lymphocyte Count, Antigens, Differentiation, Antigens, CD38, Antigens, CD, Adult, virology, mortality, Acquired Immunodeficiency Syndrome, ADP-ribosyl Cyclase

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      Abstract

      To define predictors of survival time in late human immunodeficiency virus type 1 (HIV-1) disease, long- and short-duration survivors were studied after their CD4+ T cells fell to

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      10.1086/314660
      10068581

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