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      Orthogeriatric co-management improves the outcome of long-term care residents with fragility fractures

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          Abstract

          Background

          Fragility fractures are a major health care problem worldwide. Both hip and non-hip fractures are associated with excess mortality in the years following the fracture. Residents of long-term nursing homes represent a special high-risk group for poor outcomes. Orthogeriatric co-management models of care have shown in multiple studies to have medical as well as economic advantages, but their impact on this high-risk group has not been well studied.

          Objective

          We studied the outcome of long-term care residents with hip and non-hip fractures admitted to a geriatric fracture center.

          Methods

          The study design is a single center, prospective cohort study at a level-I trauma center in Austria running a geriatric fracture center. The cohort included all fragility fracture patients aged over 70 admitted from a long-term care residence from May 2009 to November 2011. The data set consisted of 265 patients; the mean age was 86.8 ± 6.7 years, and 80 % were female. The mean follow-up after the index fracture was 789 days, with a range from 1 to 1842 days. Basic clinical and demographic data were collected at hospital admission. Functional status and mobility were assessed during follow-up at 3, 6, and 12 months. Additional outcome data regarding readmissions for new fractures were obtained from the hospital information database; mortality was crosschecked with the death registry from the governmental institute of epidemiology.

          Results

          187 (70.6 %) patients died during the follow-up period, with 78 patients (29.4 %) dying in the first year. The mean life expectancy after the index fracture was 527 (±431) days. Differences in mortality rates between hip and non-hip fracture patients were not statistically significant. Compared to reported mortality rates in the literature, hip fracture patients in this orthogeriatric-comanaged cohort had a significantly reduced one-year mortality [OR of 0.57 (95 % CI 0.31–0.85)]. After adjustment for confounders, only older age (OR 1.091; p = 0.013; CI 1.019–1.169) and a lower Parker Mobility Scale (PMS) (OR 0.737; p = 0.022; CI 0.568–0.957) remained as independent predictors. During follow-up, 62 patients (23.4 %) sustained at least one subsequent fracture, and 10 patients (3.4 %) experienced multiple fractures; 29 patients (10.9 %) experienced an additional fracture within the first year. Nearly, half (47.1 %) regained their pre-fracture mobility based on the PMS.

          Conclusion

          Despite the generally poor outcomes for fragility fracture patients residing in long-term care facilities, orthogeriatric co-management appears to improve the outcome of high-risk fragility fracture patients. One-year mortality was 29.4 % in this cohort, significantly lower than in comparable trials. Orthogeriatric co-management may also have positive impacts on both functional outcome and the risk of subsequent fractures.

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          Most cited references18

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          A new mobility score for predicting mortality after hip fracture.

          We assessed 882 patients presenting with a proximal femoral fracture by a new mobility score and by a mental test score, to determine which was of the most value in forecasting mortality at one year. Both scores gave a highly significant prediction, but the mobility score had a greater predictive value and is easier to perform.
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            Risk of subsequent fracture after low-trauma fracture in men and women.

            There are few published long-term data on absolute risk of subsequent fracture (refracture) following initial low-trauma fracture in women and fewer in men. To examine long-term risk of subsequent fracture following initial osteoporotic fracture in men and women. Prospective cohort study (Dubbo Osteoporosis Epidemiology Study) in Australia of 2245 community-dwelling women and 1760 men aged 60 years or older followed up for 16 years from July 1989 through April 2005. Incidence of first (initial) fracture and incidence of subsequent fracture according to sex, age group, and time since first fracture. Relative risk was determined by comparing risk of subsequent fracture with risk of initial fracture. There were 905 women and 337 men with an initial fracture, of whom 253 women and 71 men experienced a subsequent fracture. Relative risk (RR) of subsequent fracture in women was 1.95 (95% confidence interval [CI], 1.70-2.25) and in men was 3.47 (95% CI, 2.68-4.48). As a result, absolute risk of subsequent fracture was similar in women and men and at least as great as the initial fracture risk for a woman 10 years older. Thus, women and men aged 60 to 69 years had absolute refracture rates of 36/1000 person-years (95% CI, 26-48/1000) and 37/1000 person-years (95% CI, 23-59/1000), respectively. The increase in absolute fracture risk remained for up to 10 years, by which time 40% to 60% of surviving women and men experienced a subsequent fracture. All fracture locations apart from rib (men) and ankle (women) resulted in increased subsequent fracture risk, with highest RRs following hip (RR, 9.97; 95% CI, 1.38-71.98) and clinical vertebral (RR, 15.12; 95% CI, 6.06-37.69) fractures in younger men. In multivariate analyses, femoral neck bone mineral density, age, and smoking were predictors of subsequent fracture in women and femoral neck bone mineral density, physical activity, and calcium intake were predictors in men. After an initial low-trauma fracture, absolute risk of subsequent fracture was similar for men and women. This increased risk occurred for virtually all clinical fractures and persisted for up to 10 years.
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              Increased mortality in patients with a hip fracture-effect of pre-morbid conditions and post-fracture complications.

              In a cohort of 169,145 patients with a hip fracture and 524,010 controls we observed an excess mortality among patients compared to controls for as long as 20 years after the hip fracture. The main reason for the excess mortality was linked to the trauma that caused the hip fracture. Patients with a hip fracture have a significant excess mortality. However, it remains unclear if the mortality is linked to the pre-morbid conditions or to complications to the fracture. All subjects with a hip fracture in Denmark between 1977 and 2001 were compared with three age- and gender-matched subjects from the general population. A total of 169,145 fracture cases were compared to 524,010 controls. The cases had a much higher prevalence of co-morbidity than the controls. The mortality rate was twice as high in fracture cases compared with controls (HR = 2.26, 95% CI: 2.24-2.27). Adjustments for confounders only changed the excess mortality risk little. The mortality after the hip fracture was divided into two categories: an excess mortality of 19% within the first year following the fracture (relative survival = 0.81 compared to controls), and an excess mortality of 1.8% per year (relative survival 0.982) for every additional year following the fracture. The major causes of the excess mortality were due to complications to the fracture event (70.8% within the first 30 days). Patients with a hip fracture have a pronounced excess mortality risk. The major cause was linked to the fracture event and not to pre-existing co-morbidity.
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                Author and article information

                Contributors
                ++49 911 398 2434 , markus.gosch@klinikum-nuernberg.de
                Journal
                Arch Orthop Trauma Surg
                Arch Orthop Trauma Surg
                Archives of Orthopaedic and Trauma Surgery
                Springer Berlin Heidelberg (Berlin/Heidelberg )
                0936-8051
                1434-3916
                8 August 2016
                8 August 2016
                2016
                : 136
                : 10
                : 1403-1409
                Affiliations
                [1 ]Department of Geriatrics, Paracelsus Medical Private University Nuremberg, Hospital Nuremberg, 90408 Nuremburg, Germany
                [2 ]Department of Internal Medicine I, Gastroenterology, Endocrinology and Metabolism, Medical University of Innsbruck, Innsbruck, Austria
                [3 ]Department of Trauma Surgery and Sports Medicine, Medical University of Innsbruck, Innsbruck, Austria
                [4 ]Rochester, Division of Geriatrics, University of Rochester Medical Center, Rochester, NY USA
                [5 ]Department for Trauma-, Hand- and Plastic Surgery, LMU Munich, Munich, Germany
                Author information
                http://orcid.org/0000-0001-7720-2506
                Article
                2543
                10.1007/s00402-016-2543-4
                5025484
                27501701
                5997e185-bce9-4df2-99bf-ca8adb4fb032
                © The Author(s) 2016

                Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License ( http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

                History
                : 29 February 2016
                Categories
                Trauma Surgery
                Custom metadata
                © Springer-Verlag Berlin Heidelberg 2016

                Orthopedics
                fragility fracture,hip fracture,long-term care patients,outcome,orthogeriatric co-management

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