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      Ernest Henry Starling (1866-1927) on the Formation and Reabsorption of Lymph

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          Abstract

          Ernest Henry Starling laid the groundwork for our modern understanding of how the interstitial fluid, which he referred to as ‘lymph', is regulated. Together with his colleague, William Bayliss, he provided the crucial insight into how fluid is driven out of the capillary to form interstitial fluid. That was to measure (estimate) the capillary pressure in different parts of the circulation and to relate changes in these pressures to altered lymph formation. In addressing how interstitial fluid re-enters the circulation, he was able to show that this occurs not only via the lymphatics, but also by re-entering the capillaries, mediated by the oncotic pressure of the plasma proteins. Starling's discoveries put to rest all notions that the processes of filtration and reabsorption of fluid are mediated by the ‘vital activity' of cells. They could be explained entirely on the basis of physic-chemical forces. Based upon his insights from animal experiments, he was able to explain the genesis of edema (dropsy) in a number of disease states, including venous obstruction, cardiac disease and inflammatory conditions.

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          Most cited references 2

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          THE WISDOM OF THE BODY: The Harveian Oration, delivered before The Royal College of Physicians of London on St. Luke's Day, 1923

           E H Starling (1923)
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            Ernest Henry Starling, his law and its growing significance in the practice of medicine.

             W. B. Fye (1983)
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              Author and article information

              Journal
              NEP
              Nephron Physiol
              10.1159/issn.1660-2137
              Nephron Physiology
              S. Karger AG
              1660-2137
              2014
              June 2014
              16 May 2014
              : 126
              : 3
              : 9-17
              Affiliations
              Department of Biomedical Sciences, Cedars-Sinai Medical Center and University of California Los Angeles, Los Angeles, Calif., USA
              Author notes
              *Leon G. Fine, Department of Biomedical Sciences, Cedars-Sinai Medical Center and University of California Los Angeles, Los Angeles, CA 90048 (USA), E-Mail Leon.Fine@cshs.org
              Article
              362620 Nephron Physiol 2014;126:9-17
              10.1159/000362620
              24852245
              © 2014 S. Karger AG, Basel

              Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

              Page count
              Figures: 3, Tables: 1, Pages: 9
              Categories
              Original Paper

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