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      Skin neurogenic inflammation

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      Seminars in Immunopathology
      Springer Science and Business Media LLC

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          Abstract

          <p class="first" id="P1">The epidermis closely interacts with nerve endings and both epidermidis and nerves, produce substances for mutual sustenance. Neuropeptides, like SP and CGRP, are produced by sensory nerves in the dermis, they induce mast cells to release vasoactive amines that facilitate infiltration of neutrophils and T cells. Some receptors are more important than other in the generation of itch. Mrgprs family and the TRPA1 and Par-2 have important roles in itch and inflammation. The activation of MrgprX1 degranulate mast cells to communicate with sensory nerve and cutaneous cells for developing neurogenic inflammation. Mrgprs and TRPV4 are crucial for the generation of skin diseases like Rosacea, while SP, CGRP, somatostatin, b-endorphin, VIP and PACAP, can modulate the immune system during psoriasis development. The increased level of SP, in atopic dermatitis, induces the release of IFN g, IL-4, TNF-a and IL-10 from the peripheral blood mononuclear leukocytes. </p><p id="P2">We are finally starting to understand the intricate connections between the skin neurons and resident skin cells and how their interaction can be the key to control inflammation and from there the pathogenesis of diseases like atopic dermatitis, psoriasis and rosacea. </p>

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          Author and article information

          Journal
          Seminars in Immunopathology
          Semin Immunopathol
          Springer Science and Business Media LLC
          1863-2297
          1863-2300
          May 2018
          April 30 2018
          May 2018
          : 40
          : 3
          : 249-259
          Article
          10.1007/s00281-018-0675-z
          6047518
          29713744
          59a5695a-3a6c-4060-914e-489be86496be
          © 2018

          http://www.springer.com/tdm

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