20
views
0
recommends
+1 Recommend
1 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Possible Therapeutic Effects of Adjuvant Quercetin Supplementation Against Early-Stage COVID-19 Infection: A Prospective, Randomized, Controlled, and Open-Label Study

      case-report

      Read this article at

      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Background

          Quercetin, a well-known naturally occurring polyphenol, has recently been shown by molecular docking, in vitro and in vivo studies to be a possible anti-COVID-19 candidate. Quercetin has strong antioxidant, anti-inflammatory, immunomodulatory, and antiviral properties, and it is characterized by a very high safety profile, exerted in animals and in humans. Like most other polyphenols, quercetin shows a very low rate of oral absorption and its clinical use is considered by most of modest utility. Quercetin in a delivery-food grade system with sunflower phospholipids (Quercetin Phytosome ®, QP) increases its oral absorption up to 20-fold.

          Methods

          In the present prospective, randomized, controlled, and open-label study, a daily dose of 1000 mg of QP was investigated for 30 days in 152 COVID-19 outpatients to disclose its adjuvant effect in treating the early symptoms and in preventing the severe outcomes of the disease.

          Results

          The results revealed a reduction in frequency and length of hospitalization, in need of non-invasive oxygen therapy, in progression to intensive care units and in number of deaths. The results also confirmed the very high safety profile of quercetin and suggested possible anti-fatigue and pro-appetite properties.

          Conclusion

          QP is a safe agent and in combination with standard care, when used in early stage of viral infection, could aid in improving the early symptoms and help in preventing the severity of COVID-19 disease. It is suggested that a double-blind, placebo-controlled study should be urgently carried out to confirm the results of our study.

          Related collections

          Most cited references30

          • Record: found
          • Abstract: found
          • Article: found
          Is Open Access

          Overviews of Biological Importance of Quercetin: A Bioactive Flavonoid

          Antioxidants are substances that may protect cells from the damage caused by unstable molecules such as free radicals. Flavonoids are phenolic substances widely found in fruits and vegetables. The previous studies showed that the ingestion of flavonoids reduces the risk of cardiovascular diseases, metabolic disorders, and certain types of cancer. These effects are due to the physiological activity of flavonoids in the reduction of oxidative stress, inhibiting low-density lipoproteins oxidation and platelet aggregation, and acting as vasodilators in blood vessels. Free radicals are constantly generated resulting in extensive damage to tissues leading to various disease conditions such as cancer, Alzheimer's, renal diseases, cardiac abnormalities, etc., Medicinal plants with antioxidant properties play a vital functions in exhibiting beneficial effects and employed as an alternative source of medicine to mitigate the disease associated with oxidative stress. Flavonoids have existed over one billion years and possess wide spectrum of biological activities that might be able to influence processes which are dysregulated in a disease. Quercetin, a plant pigment is a potent antioxidant flavonoid and more specifically a flavonol, found mostly in onions, grapes, berries, cherries, broccoli, and citrus fruits. It is a versatile antioxidant known to possess protective abilities against tissue injury induced by various drug toxicities.
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Candidate drugs against SARS-CoV-2 and COVID-19

            Graphical abstract Coronavirus SARS-CoV-2 enters host cells via ligation of its spike protein (S glycoprotein) with host cell ACE2 receptor that is primed by TMPRSS2 protease. ACE2- and TMPRSS2-mediated cell entry can be blocked by experimental and established drugs. Virus replication and assembly can be inhibited by antiviral drugs targeting viral RNA-dependent RNA polymerase (RdRP) and main protease (Mpro).
              Bookmark
              • Record: found
              • Abstract: found
              • Article: found
              Is Open Access

              Antioxidant Activities of Quercetin and Its Complexes for Medicinal Application

              Quercetin is a bioactive compound that is widely used in botanical medicine and traditional Chinese medicine due to its potent antioxidant activity. In recent years, antioxidant activities of quercetin have been studied extensively, including its effects on glutathione (GSH), enzymatic activity, signal transduction pathways, and reactive oxygen species (ROS) caused by environmental and toxicological factors. Chemical studies on quercetin have mainly focused on the antioxidant activity of its metal ion complexes and complex ions. In this review, we highlight the recent advances in the antioxidant activities, chemical research, and medicinal application of quercetin.
                Bookmark

                Author and article information

                Journal
                Int J Gen Med
                Int J Gen Med
                ijgm
                ijgm
                International Journal of General Medicine
                Dove
                1178-7074
                08 June 2021
                2021
                : 14
                : 2359-2366
                Affiliations
                [1 ]Scientific & Research Department, Velleja Research , Milan, Italy
                [2 ]Digestive Endoscopy, Fondazione Poliambulanza , Brescia, Italy
                [3 ]Department of Internal Medicine and Therapeutics, University of Pavia , Pavia, Italy
                [4 ]Laboratory of Molecular Medicine, University of Pavia , Pavia, Italy
                [5 ]Department of Biomolecular Sciences (DISB), University of Urbino , Urbino, Italy
                [6 ]Indena Research and Development Department , Milan, Italy
                [7 ]Chemistry Research Laboratory, Department of Chemistry, University of Oxford , Oxford, UK
                [8 ]University of Health Sciences , Lahore, Pakistan
                [9 ]Department of Molecular Pathology, Dow International Medical College, Dow University of Health Sciences , Karachi, Pakistan
                [10 ]Department of Pathology, Liaquat University of Medical & Health Sciences , Jamshoro, Sindh, Pakistan
                [11 ]Department of Obstetrics and Gynaecology, Liaquat University of Medical & Health Sciences , Jamshoro, Sindh, Pakistan
                [12 ]Department of Paediatric Dow International Medical College, Dow University of Health Sciences , Karachi, Pakistan
                [13 ]Department of Medicine, Liaquat University of Medical & Health Sciences , Jamshoro, Sindh, Pakistan
                [14 ]Shifa College of Pharmaceutical Sciences, Shifa Tameer-e-Millat University , Islamabad, Pakistan
                Author notes
                Correspondence: Francesco Di Pierro Scientific & Research Department, Velleja Research , Milan, ItalyTel +39 023510848Fax +39 023 511894 Email f.dipierro@vellejaresearch.com
                Author information
                http://orcid.org/0000-0001-6654-8675
                http://orcid.org/0000-0003-3573-4760
                http://orcid.org/0000-0002-3922-9115
                http://orcid.org/0000-0003-2819-943X
                http://orcid.org/0000-0002-4380-9577
                Article
                318720
                10.2147/IJGM.S318720
                8197660
                34135619
                59a76a4e-438f-4be6-848c-a9c9433bb204
                © 2021 Di Pierro et al.

                This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License ( http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms ( https://www.dovepress.com/terms.php).

                History
                : 06 May 2021
                : 25 May 2021
                Page count
                Figures: 0, Tables: 14, References: 30, Pages: 8
                Categories
                Clinical Trial Report

                Medicine
                sars-cov-2,infectious diseases,coronavirus,pneumonia,botanicals,phytosome®
                Medicine
                sars-cov-2, infectious diseases, coronavirus, pneumonia, botanicals, phytosome®

                Comments

                Comment on this article