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      Antibody-Coated Bacteria in the Urinary Sediment of Rats with Experimental Pyelonephritis

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          Abstract

          The appearance of antibody-coated bacteria in urinary sediment has been evaluated in rats with experimental pyelonephritis. At day 7 after induction of pyelonephritis, 9 out of 11 rats demonstrated antibody-coated bacteria in the urinary sediment. The other 2 rats never had a positive urinary sediment. Following removal of the pyelonephritic kidneys, antibody-coated bacteria disappeared in 7 of the 9 previously positive rats. In the 2 rats which continued to show antibody-coated bacteria, the infecting organisms were found in the remaining kidney. The 2 rats which never developed antibody-coated bacteria in urinary sediment had a higher than normal serum antibody titer, and 1 rat with antibody-coated bacteria showed a normal serum antibody titer. It is concluded that although the search for antibody-coated bacteria in urinary sediment is a very useful technique, its negativity does not exclude upper urinary tract involvement; in the case of renal parenchymal infection, immunity is not the same at the systemic and the local site.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1978
          1978
          02 December 2008
          : 21
          : 3
          : 165-169
          Affiliations
          Istituto di Clinica Medica I, Istituto di Microbiologia and Istituto di Clinica Chirurgica, University of Padova, Padova
          Article
          181388 Nephron 1978;21:165–169
          10.1159/000181388
          353576
          © 1978 S. Karger AG, Basel

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          Page count
          Pages: 5
          Categories
          Original Paper

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