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      Gordon Murray: Heparin, Hemodialysis and Hubris


      American Journal of Nephrology

      S. Karger AG

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          Gordon Murray (1894–1976), a brilliant and innovative surgeon who spent the majority of his professional career at the University of Toronto, Ont., Canada, is properly credited with having performed the first successful hemodialyses in humans in North America. Neither he nor Kolff, working in the Netherlands, were aware of each other’s work during the middle 1940s when wartime hampered communication. Murray’s extensive investigations and experience in the use of heparin in vascular surgery laid the groundwork for the use of this anticoagulant with the artificial kidney. He first designed a coil dialyzer in which cellophane tubing was wound about a steel frame. His second-generation apparatus was a plate dialyzer. In all, he performed dialysis on 11 patients with presumed acute renal failure, 50% of whom survived. Those who died succumbed to sepsis or irreversible chronic renal failure. Not much has changed in 50 years.

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          Presidential address: [ldquo ]Give us the tools...[rdquo ]

           Ronald Baird (1990)

            Author and article information

            Am J Nephrol
            American Journal of Nephrology
            S. Karger AG
            July 2002
            27 June 2002
            : 22
            : 2-3
            : 271-277
            Department of Cell and Molecular Physiology, University of North Carolina at Chapel Hill, N.C., and Becker Medical Library, Washington University School of Medicine, St. Louis, Mo., USA
            63773 Am J Nephrol 2002;22:271–277
            © 2002 S. Karger AG, Basel

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            Page count
            Figures: 5, References: 12, Pages: 7
            Self URI (application/pdf):
            History of Dialysis and Transplantation

            Cardiovascular Medicine, Nephrology


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