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      Gordon Murray: Heparin, Hemodialysis and Hubris

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      American Journal of Nephrology

      S. Karger AG

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          Abstract

          Gordon Murray (1894–1976), a brilliant and innovative surgeon who spent the majority of his professional career at the University of Toronto, Ont., Canada, is properly credited with having performed the first successful hemodialyses in humans in North America. Neither he nor Kolff, working in the Netherlands, were aware of each other’s work during the middle 1940s when wartime hampered communication. Murray’s extensive investigations and experience in the use of heparin in vascular surgery laid the groundwork for the use of this anticoagulant with the artificial kidney. He first designed a coil dialyzer in which cellophane tubing was wound about a steel frame. His second-generation apparatus was a plate dialyzer. In all, he performed dialysis on 11 patients with presumed acute renal failure, 50% of whom survived. Those who died succumbed to sepsis or irreversible chronic renal failure. Not much has changed in 50 years.

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          Most cited references 1

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          Presidential address: [ldquo ]Give us the tools...[rdquo ]

           Ronald Baird (1990)
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            Author and article information

            Journal
            AJN
            Am J Nephrol
            10.1159/issn.0250-8095
            American Journal of Nephrology
            S. Karger AG
            978-3-8055-7424-2
            978-3-318-00852-4
            0250-8095
            1421-9670
            2002
            July 2002
            27 June 2002
            : 22
            : 2-3
            : 271-277
            Affiliations
            Department of Cell and Molecular Physiology, University of North Carolina at Chapel Hill, N.C., and Becker Medical Library, Washington University School of Medicine, St. Louis, Mo., USA
            Article
            63773 Am J Nephrol 2002;22:271–277
            10.1159/000063773
            12097752
            © 2002 S. Karger AG, Basel

            Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

            Page count
            Figures: 5, References: 12, Pages: 7
            Product
            Self URI (application/pdf): https://www.karger.com/Article/Pdf/63773
            Categories
            History of Dialysis and Transplantation

            Cardiovascular Medicine, Nephrology

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