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      Urinary Histamine Excretion in Proteinuric States

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          The kidney possesses the enzymatic steps required for the biosynthesis of histamine and this autocoid may play a role in modulating renal hemodynamics and the local inflammatory response to immunologic injury. We, therefore, measured urinary histamine. N-methylhistamine and N-methylimidazole acetic acid concentrations in patients with proteinuria due to a variety of disease states – idiopathic nephrotic syndrome (n = 19), systemic lupus erythematosus (n = 10), refractory focal segmental glomerulosclerosis (n = 10) and control patients (n = 16). Urinary histamine concentration was significantly reduced in treatment-responsive idiopathic nephrotic syndrome during disease relapse compared to remission (16.6 ± 3.6 vs. 28.4 ± 4.8 μmol/mol creatinine, p < 0.02). The levels were also depressed in children with other causes of persistent proteinuria, including systemic lupus erythematosus (10.3 ± 4.0 μmol/mol creatinine) and focal segmental glomerulosclerosis (14.6 ± 2.8 μmol/mol creatinine) compared to normal controls (31.4 ± 4.7μmol/mol creatinine). The decreased urinary excretion of histamine and its metabolites in patients with proteinuria may be a result of immunologically mediated mesangial cell injury or represent a compensatory hemodynamic response to limit urinary protein losses.

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          Author and article information

          S. Karger AG
          05 December 2008
          : 47
          : 1
          : 12-16
          Department of Pediatrics, Schneider Children’s Hospital, New Hyde Park, and State University of New York-Downstate Medical Center, Brooklyn, New York, N.Y., USA; Central Laboratory for Clinical Chemistry, University Hospital, Groningen, Netherlands
          184449 Nephron 1987;47:12–16
          © 1987 S. Karger AG, Basel

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          Page count
          Pages: 5
          Original Paper

          Cardiovascular Medicine, Nephrology

          Proteinuria, Nephrotic syndrome, Urinary histamine


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