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      Podophyllotoxin: distribution, sources, applications and new cytotoxic derivatives.

      Toxicon

      Cytotoxins, chemistry, pharmacology, Etoposide, analogs & derivatives, Lignans, classification, Organophosphorus Compounds, Plants, Toxic, Podophyllotoxin, metabolism, Teniposide, Tumor Cells, Cultured, drug effects

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          Abstract

          Several podophyllotoxin derivatives modified in the A, B, C, D and E rings were prepared from podophyllotoxin and methyl isoxazopodophyllic acid and evaluated for their cytotoxicity on several neoplastic cell lines. Chemical transformations performed on these compounds have yielded derivatives more potent and more selective that the parent compound. Most of the compounds maintained their cytotoxicity at the microM level. Distribution, biosynthesis, production, biotechnology, applications and synthesis have also been reviewed.

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          Journal
          15302526
          10.1016/j.toxicon.2004.05.008

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