Activated macrophages create lineage-specific microenvironments for pancreatic acinar- and β-cell regeneration in mice.

Abstract

Although the cells that contribute to pancreatic regeneration have been widely studied, little is known about the mediators of this process. During tissue regeneration, infiltrating macrophages debride the site of injury and coordinate the repair response. We investigated the role of macrophages in pancreatic regeneration in mice.