The effect of marine n-3 polyunsaturated fatty acids on cardiac autonomic and hemodynamic function in patients with psoriatic arthritis: a randomised, double-blind, placebo-controlled trial

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

Background

The aim of this study was to investigate the effect of marine n-3 polyunsaturated fatty acids (PUFA) on cardiac autonomic function and vascular function in patients with psoriatic arthritis.

Methods

The study was conducted as a randomized, double-blind, placebo-controlled trial, where 145 patients with psoriatic arthritis were supplemented with 3 g of n-3 PUFA or olive oil (control) daily for 24 weeks. Blood pressure, heart rate, heart rate variability (HRV), central blood pressure, pulse wave velocity (PWV) and fatty acid composition of granulocytes, were determined at baseline and after supplementation.

Results

At baseline we found a significant difference in the mean of all normal RR intervals (inverse of heart rate, vary from beat to beat) when comparing subjects with the highest vs the lowest fish intake ( p = 0.03). After supplementation for 24 weeks there was a trend towards an increase in RR ( p = 0.13) and decrease in heart rate ( p = 0.12) comparing the n-3 PUFA group with the control group. However, per-protocol analysis showed significantly increased RR ( p = 0.01) and lowered heart rate ( p = 0.01) in the n-3 PUFA supplemented patients compared with controls. Blood pressure, PWV and Central blood pressure did not change after supplementation with n-3 PUFA. Adjustment for disease activity and conventional cardiovascular risk factors did not change the results.

Conclusions

Marine n-3 PUFA increased RR intervals in patients with psoriatic arthritis which may suggest a protective effect of n-3 PUFA against cardiovascular disease in this population.

Trial registration

Clinicaltrials.gov Identifier: NCT01818804

Related collections

Most cited references 44

Record: found
Abstract: found
Article: not found

Impact of Reduced Heart Rate Variability on Risk for Cardiac Events: The Framingham Heart Study

Hisako Tsuji, Martin Larson, Ferdinand J Venditti … (1996)

Although heart rate variability (HRV) is altered in a variety of pathological conditions, the association of reduced HRV with risk for new cardiac events has not been studied in a large community-based population. The first 2 hours of ambulatory ECG recordings obtained on subjects of the Framingham Heart Study who were free of clinically apparent coronary heart disease or congestive heart failure were reprocessed to assess HRV. Five frequency-domain measures and three time-domain measures were obtained. The associations between HRV measures and the incidence of new cardiac events (angina pectroris, myocardial infarction, coronary heart disease death, or congestive heart failure) were assessed with proportional hazards regression analyses. There were 2501 eligible subjects with a mean age of 53 years. During a mean follow-up of 3.5 years, cardiac events occurred in 58 subjects. After adjustment for age, sex, cigarette smoking, diabetes, left ventricular hypertrophy, and other relevant risk factors, all HRV measures except the ratio of low-frequency to high-frequency power were significantly associated with risk for a cardiac event (P = .0016 to .0496). A one-standard deviation decrement in the standard deviation of total normal RR intervals (natural log transformed) was associated with a hazard ratio of 1.47 for new cardiac events (95% confidence interval of 1.16 to 1.86). The estimation of HRV by ambulatory monitoring offers prognostic information beyond that provided by the evaluation of traditional cardiovascular disease risk factors.

0 comments Cited 346 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: found
Article: not found

Baroreflex sensitivity and heart-rate variability in prediction of total cardiac mortality after myocardial infarction. ATRAMI (Autonomic Tone and Reflexes After Myocardial Infarction) Investigators.

M T La Rovere, J Bigger, F I Marcus … (1998)

Experimental evidence suggests that autonomic markers such as heart-rate variability and baroreflex sensitivity (BRS) may contribute to postinfarction risk stratification. There are clinical data to support this concept for heart-rate variability. The main objective of the ATRAMI study was to provide prospective data on the additional and independent prognostic value for cardiac mortality of heart-rate variability and BRS in patients after myocardial infarction in whom left-ventricular ejection fraction (LVEF) and ventricular arrhythmias were known. This multicentre international prospective study enrolled 1284 patients with a recent ( 105 ms, BRS >6.1 ms per mm Hg). The association of low SDNN or BRS with LVEF below 35% carried a relative risk of 6.7 (3.1-14.6) or 8.7 (4.3-17.6), respectively, compared with patients with LVEF above 35% and less compromised SDNN (> or = 70 ms) and BRS (> or = 3 ms per mm Hg). ATRAMI provides clinical evidence that after myocardial infarction the analysis of vagal reflexes has significant prognostic value independently of LVEF and of ventricular arrhythmias and that it significantly adds to the prognostic value of heart-rate variability.

0 comments Cited 271 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: found
Article: not found

Prospective evaluation of a method for estimating ascending aortic pressure from the radial artery pressure waveform.

A Pauca, M F O'Rourke, N Kon (2001)

Pressure wave reflection in the upper limb causes amplification of the arterial pulse so that radial systolic and pulse pressures are greater than in the ascending aorta. Wave transmission properties in the upper limbs (in contrast to the descending aorta and lower limbs) change little with age, disease, and drug therapy in adult humans. Such consistency has led to use of a generalized transfer function to synthesize the ascending aortic pressure pulse from the radial pulse. Validity of this approach was tested for estimation of aortic systolic, diastolic, pulse, and mean pressures from the radial pressure waveform. Ascending aortic and radial pressure waveforms were recorded simultaneously at cardiac surgery, before initiation of cardiopulmonary bypass, with matched, fluid-filled manometer systems in 62 patients under control conditions and during nitroglycerin infusion. Aortic pressure pulse waves, generated from the radial pulse, showed agreement with the measured aortic pulse waves with respect to systolic, diastolic, pulse, and mean pressures, with mean differences <1 mm Hg. Control differences in Bland-Altman plots for mean+/-SD in mm Hg were systolic, 0.0+/-4.4; diastolic, 0.6+/-1.7; pulse, -0.7+/-4.2; and mean pressure, -0.5+/-2.0. For nitroglycerin infusion, differences respectively were systolic, -0.2+/-4.3; diastolic, 0.6+/-1.7; pulse, -0.8+/-4.1; and mean pressure, -0.4+/-1.8. Differences were within specified limits of the Association for the Advancement of Medical Instrumentation SP10 criteria. In contrast, differences between recorded radial and aortic systolic and pulse pressures were well outside the criteria (respectively, 15.7+/-8.4 and 16.3+/-8.5 for control and 14.5+/-7.3 and 15.1+/-7.3 mm Hg for nitroglycerin). Use of a generalized transfer function to synthesize radial artery pressure waveforms can provide substantially equivalent values of aortic systolic, pulse, mean, and diastolic pressures.

0 comments Cited 209 times – based on 0 reviews      Review now

Bookmark

All references

Author and article information

Contributors

Salome Kristensen:

ORCID: http://orcid.org/0000-0001-5812-5234

+4597664015 , sakr@rn.dk

Erik Berg Schmidt: ebs@rn.dk

Annette Schlemmer: a.schlemmer@rn.dk

Claus Rasmussen: clara@rn.dk

Esther Lindgreen: esli@rn.dk

Martin Berg Johansen: martin.johansen@rn.dk

Jeppe Hagstrup Christensen: jeppe.hagstrup.christensen@rn.dk

Journal

Journal ID (nlm-ta): Lipids Health Dis

Journal ID (iso-abbrev): Lipids Health Dis

Title: Lipids in Health and Disease

Publisher: BioMed Central (London )

ISSN (Electronic): 1476-511X

Publication date (Electronic): 12 December 2016

Publication date PMC-release: 12 December 2016

Publication date Collection: 2016

Volume: 15

Electronic Location Identifier: 216

Affiliations

[1 ]Department of Rheumatology, Aalborg University Hospital, Reberbansgade 14, 9000 Aalborg, Denmark

[2 ]Department of Cardiology, Aalborg University Hospital, Department of Clinical Medicine, Aalborg University, 9000 Aalborg, Denmark

[3 ]Department of Rheumatology, North Denmark Regional Hospital, 9800 Hjørring, Denmark

[4 ]Department of Cardiology and Unit of Clinical Biostatistics and Bioinformatics, Aalborg University Hospital, 9000 Aalborg, Denmark

[5 ]Department of Nephrology, Aalborg University Hospital, Department of Clinical Medicine, Aalborg University, 9000 Aalborg, Denmark

Author information

Salome Kristensen http://orcid.org/0000-0001-5812-5234

Article

Publisher ID: 382

DOI: 10.1186/s12944-016-0382-5

PMC ID: 5154054

PubMed ID: 27955663

SO-VID: 5a28332b-8f8e-40b6-8420-18f2b22c0c89

License:

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License ( http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

History

Date received : 19 August 2016

Date accepted : 29 November 2016

Funding

Funded by: Aalborg University Hospital Research Foundation

Funded by: The Medical Research Foundation of the Northern Region, Denmark

Funded by: The Danish Rheumatism Association

Funded by: Danish Psoriasis Foundation

Funded by: The Aage Bang Foundation

Funded by: Abbvie Foundation

Funded by: Heinrich Kopps Foundation

Funded by: Jacob Madsen and wife Olga Madsen Foundation

Custom metadata

ScienceOpen disciplines: Biochemistry

Keywords: psoriatic arthritis,n-3 pufa,heart rate variability,cardiac autonomic function,pulse wave velocity,arterial stiffness

Data availability:

ScienceOpen disciplines: Biochemistry

Keywords: psoriatic arthritis, n-3 pufa, heart rate variability, cardiac autonomic function, pulse wave velocity, arterial stiffness

The effect of marine n-3 polyunsaturated fatty acids on cardiac autonomic and hemodynamic function in patients with psoriatic arthritis: a randomised, double-blind, placebo-controlled trial

Read this article at

Abstract

Background

Methods

Results

Conclusions

Trial registration

Related collections

Drug_transporters

Most cited references 44

Impact of Reduced Heart Rate Variability on Risk for Cardiac Events: The Framingham Heart Study

Baroreflex sensitivity and heart-rate variability in prediction of total cardiac mortality after myocardial infarction. ATRAMI (Autonomic Tone and Reflexes After Myocardial Infarction) Investigators.

Prospective evaluation of a method for estimating ascending aortic pressure from the radial artery pressure waveform.

Author and article information

Contributors

Journal

Affiliations

Author information

Article

History

Funding

Categories

Custom metadata

Comments

Comment on this article

Similar content 144

Cited by 13

Most referenced authors 1,237