20
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Psoriasis and Microbiota: A Systematic Review

      review-article

      Read this article at

      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Background: Recent advances have highlighted the crucial role of microbiota in the pathophysiology of chronic inflammatory diseases as well as its impact on the efficacy of therapeutic agents. Psoriasis is a chronic, multifactorial inflammatory skin disorder, which has a microbiota distinct from healthy, unaffected skin. Aim: Through an extensive review of the literature, we aim to discuss the skin and gut microbiota and redefine their role in the pathogenesis of psoriasis. Conclusions: Unfortunately, the direct link between the skin microbiota and the pathogenesis of psoriasis remains to be clearly established. Apart from improving the course of psoriasis, selective modulation of the microbiota may increase the efficacy of medical treatments as well as attenuate their side effects.

          Related collections

          Most cited references55

          • Record: found
          • Abstract: found
          • Article: not found

          The gut microbiome in health and in disease

          Recent technological advancements and expanded efforts have led to a tremendous growth in the collective knowledge of the human microbiome. This review will highlight some of the important recent findings in this area of research.
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Innate immune recognition of the microbiota promotes host-microbial symbiosis.

            Pattern-recognition receptors (PRRs) are traditionally known to sense microbial molecules during infection to initiate inflammatory responses. However, ligands for PRRs are not exclusive to pathogens and are abundantly produced by the resident microbiota during normal colonization. Mechanism(s) that underlie this paradox have remained unclear. Recent studies reveal that gut bacterial ligands from the microbiota signal through PRRs to promote development of host tissue and the immune system, and protection from disease. Evidence from both invertebrate and vertebrate models reveals that innate immune receptors are required to promote long-term colonization by the microbiota. This emerging perspective challenges current models in immunology and suggests that PRRs may have evolved, in part, to mediate the bidirectional cross-talk between microbial symbionts and their hosts.
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Functions of the skin microbiota in health and disease.

              The skin, the human body's largest organ, is home to a diverse and complex variety of innate and adaptive immune functions. Despite this potent immune system present at the cutaneous barrier, the skin encourages colonization by microorganisms. Characterization these microbial communities has enhanced our knowledge of the ecology of organisms present in normal skin; furthermore, studies have begun to bring to light the intimate relationships shared between host and resident microbes. In particular, it is apparent that just as host immunological factors and behaviors shape the composition of these communities, microbes present on the skin greatly impact the functions of human immunity. Thus, today the skin immune system should be considered a collective mixture of elements from the host and microbes acting in a mutualistic relationship. In this article we will review recent findings of the interactions of skin microbial communities with host immunity, and discuss the role that dysbiosis of these communities plays in diseases of the skin.
                Bookmark

                Author and article information

                Journal
                Diseases
                Diseases
                diseases
                Diseases
                MDPI
                2079-9721
                02 June 2018
                June 2018
                : 6
                : 2
                : 47
                Affiliations
                [1 ]Dermatology Department, Erasme Hospital, Université Libre de Bruxelles, Route de Lennik 808, Anderlecht, 1070 Brussels, Belgium
                [2 ]Dermatology Department, Sir Paul Boffa Hospital, 1491 Floriana, Malta; dillon.mintoff@ 123456gov.mt
                [3 ]Medecine Faculty, Université Libre de Bruxelles, 1070 Brussels, Belgium; bschnebe@ 123456ulb.ac.be
                [4 ]Dermatology Department, Erasmus Medical Center, 3000 Rotterdam, The Netherlands; h.thio@ 123456erasmusmc.nl
                Author notes
                [* ]Correspondence: farida.benhadou@ 123456erasme.ulb.ac.be ; Tel.: +32-555-46-12
                Author information
                https://orcid.org/0000-0003-3705-0119
                Article
                diseases-06-00047
                10.3390/diseases6020047
                6023392
                29865237
                5a2c285a-d612-44bc-b9ad-839f9fa6ff1f
                © 2018 by the authors.

                Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( http://creativecommons.org/licenses/by/4.0/).

                History
                : 05 May 2018
                : 01 June 2018
                Categories
                Review

                psoriasis,microbiota,probiotics,prebiotics
                psoriasis, microbiota, probiotics, prebiotics

                Comments

                Comment on this article