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      The “Skipped Segment Screw” Construct: An Alternative to Conventional Lateral Mass Fixation–Biomechanical Analysis in a Porcine Cervical Spine Model

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          Abstract

          Study Design

          Cadaveric biomechanical study.

          Purpose

          We compared the “skipped segment screw” (SSS) construct with the conventional “all segment screw” (ASS) construct for cervical spine fixation in six degrees of freedom in terms of the range of motion (ROM).

          Overview of Literature

          Currently, no clear guidelines are available in the literature for the configuration of lateral mass (LM) screwrod fixation for cervical spine stabilization. Most surgeons tend to insert screws bilaterally at all segments from C3 to C6 with the assumption that implants at every level will provide maximum stability.

          Methods

          Six porcine cervical spine specimens were harvested from fresh 6–9-month-old pigs. Each specimen was sequentially tested in the following order: intact uninstrumented (UIS), SSS (LM screws in C3, C5, and C7 bilaterally), and ASS (LM screws in C3–C7 bilaterally). Biomechanical testing was performed with a force of 2 Nm in six degrees of freedom and 3D motion tracking was performed.

          Results

          The two-tailed paired t-test was used for statistical analysis. There was a significant decrease in ROM in instrumented specimens compared with that in UIS specimens in all six degrees of motion ( p<0.05), whereas there was no significant difference in ROM between the different types of constructs (SSS and ASS).

          Conclusions

          Because both configurations provide comparable stability under physiological loading, we provide a biomechanical basis for the use of SSS configuration owing to its potential clinical advantages, such as relatively less bulk of implants within a small operative field, relative ease of manipulating the rod into position, shorter surgical time, less blood loss, lower risk of screw-related complications, less implant-related costs, and most importantly, no compromise in the required stability needed until fusion.

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          Most cited references11

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          The use of a quadruped as an in vivo model for the study of the spine - biomechanical considerations.

          Animal models in spine research are often criticized for being irrelevant to the human situation due to the horizontal position of the spine. Whether this is justified from a biomechanical point of view can be questioned. The purpose of the study reported here was to provide arguments that a quadruped can be a valuable in vivo model for the study of the spine in spite of its horizontal position. Relevant literature is reviewed, and biomechanical analyses were made of the standing and walking quadruped. Further, the vertebral trabecular bone architecture was quantitatively analysed by computer and interpreted in the light of Wolff's law. Due to the fact that spinal segments cannot withstand substantial bending moments, additional tensile forces from muscles and ligaments are necessary to control the posture of a quadruped spine. As a consequence, the spine is mainly loaded by axial compression. The trabeculae in a goat's vertebral body were found to course horizontally between its anterior and posterior endplates, implying that the main load within the vertebral body was indeed an axial compression force. The density of the vertebrae of quadrupeds is higher than that of human vertebrae, suggesting that the quadruped has to sustain higher axial compression stresses. The quadruped spine is mainly loaded along its long axis, just like the human spine. The quadruped can thus be a valuable animal model for spine research. An important point of difference is the higher axial compression stress in quadrupeds, which leads to higher bone densities in the vertebrae. This puts some limitations on the transferability of the results of animal experiments to the human situation.
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            Are the spines of calf, pig and sheep suitable models for pre-clinical implant tests?

            Pre-clinical in vitro tests are needed to evaluate the biomechanical performance of new spinal implants. For such experiments large animal models are frequently used. Whether these models allow any conclusions concerning the implant's performance in humans is difficult to answer. The aim of the present study was to investigate whether calf, pig or sheep spine specimens may be used to replace human specimens in in vitro flexibility and cyclic loading tests with two different implant types. First, a dynamic and a rigid fixator were tested using six human, six calf, six pig and six sheep thoracolumbar spine specimens. Standard flexibility tests were carried out in a spine tester in flexion/extension, lateral bending and axial rotation in the intact state, after nucleotomy and after implantation. Then, the Coflex interspinous implant was tested for flexibility and intradiscal pressure using another six human and six calf lumbar spine segments. Loading was carried out as described above in the intact condition, after creation of a defect and after implantation. The fixators were most easily implantable into the calf. Qualitatively, they had similar effects on ROM in all species, however, the degree of stability achieved differed. Especially in axial rotation, the ROM of sheep, pig and calf was partially less than half the human ROM. Similarly, implantation of the Coflex interspinous implant caused the ROM to either increase in both species or to decrease in both of them, however, quantitatively, differences were observed. This was also the case for the intradiscal pressure. In conclusion, animal species, especially the calf, may be used to get a first idea of how a new pedicle screw system or an interspinous implant behaves in in vitro flexibility tests. However, the effects on ROM and intradiscal pressure have to be expected to differ in magnitude between animal and human. Therefore, the last step in pre-clinical implant testing should always be an experiment with human specimens.
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              Posterior cervical arthrodesis and stabilization with a lateral mass plate. Clinical and computed tomographic evaluation of lateral mass screw placement and associated complications.

              A prospective study evaluating screw position and associated complications in 21 consecutive patients treated with a plate and screw fixation system applied to the lateral masses of the cervical spine. To determine the clinical safety of lateral mass screws by determining their anatomic location and clinical complications in a consecutive patient series. Lateral mass plating has been advocated for procedures in which wiring techniques cannot be used, especially in instances in which the posterior elements are deficient. The first 21 consecutive patients who underwent posterior cervical arthrodesis and lateral mass plating with a single fixation system were reviewed prospectively. Computed tomography scans taken after surgery were reviewed independently by an orthopedic spinal surgeon and by a radiologist to evaluate screw tip position. Clinical and radiographic outcome was assessed at each visit after surgery. Ten of 164 (6.1%) lateral mass screws were malpositioned in six patients. Three symptomatic patients underwent four additional operative procedures to remove or replace the malpositioned screws. All patients had radiographic union, and no patient developed mechanical implant failure requiring removal of instrumentation. Radiographic evaluation noted that 17% of the screws were in the central axial zone of the lateral mass on computed tomography. Lateral mass plating was associated with no vertebral artery or spinal cord injury. There was a 1.8%-per-screw risk of radiculopathy, which corresponds with published cadaveric studies. Radicular symptoms improved with screw removal in each case. The advantages of segmental fixation achieved with lateral mass plates and screws must be weighed against the risk of radiculopathy.
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                Author and article information

                Journal
                Asian Spine J
                Asian Spine J
                ASJ
                Asian Spine Journal
                Korean Society of Spine Surgery
                1976-1902
                1976-7846
                October 2017
                11 October 2017
                : 11
                : 5
                : 733-738
                Affiliations
                [1 ]Department of Spinal Disorders, Christian Medical College, Ida Scudder Road, Vellore, India.
                [2 ]Division of Photonics, Vellore Institute of Technology, Near Katpadi Road, Vellore, India.
                Author notes
                Corresponding author: Kedar Prashant Padhye. Department of Orthopaedics, IWK Health Centre, 5980 University Ave, Halifax, Nova Scotia, B3K 6R8, Canada. Tel: +1-902-210-2016, Fax: +1-1-902-470-2275, kedarorth@ 123456gmail.com
                Author information
                https://orcid.org/0000-0001-6257-717X
                https://orcid.org/0000-0003-2923-3089
                https://orcid.org/0000-0002-6452-0043
                https://orcid.org/0000-0001-7404-5744
                https://orcid.org/0000-0001-9187-5109
                Article
                10.4184/asj.2017.11.5.733
                5662856
                5a3533a4-ed5f-438a-b51d-d1a888c0e266
                Copyright © 2017 by Korean Society of Spine Surgery

                This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                : 30 January 2017
                : 11 March 2017
                : 15 March 2017
                Categories
                Clinical Study

                Orthopedics
                cadaver,cervical vertebrae,laminectomy,swine,biomechanics
                Orthopedics
                cadaver, cervical vertebrae, laminectomy, swine, biomechanics

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