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      Anticonvulsive activity of Butea monosperma flowers in laboratory animals

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      Pharmacology Biochemistry and Behavior
      Elsevier BV

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          Abstract

          The bioassay-guided fractionation of dried flowers of Butea monosperma (BM) was carried out to isolate the active principle responsible for its anticonvulsant activity. The petroleum ether extract was fractionated by column chromatography using solvents of varying polarity such as n-hexane, n-hexane:ethyl acetate, ethyl acetate, and methanol. The anticonvulsive principle of B. monosperma was found to be a triterpene (TBM) present in the n-hexane:ethyl acetate (1:1) fraction of the petroleum ether extract. TBM exhibited anticonvulsant activity against seizures induced by maximum electroshock (MES) and its PD(50) was found to be 34.2+/-18.1 mg/kg. TBM also inhibited seizures induced by pentylenetetrazol (PTZ), electrical kindling, and the combination of lithium sulfate and pilocarpine nitrate (Li-Pilo). However, TBM was not effective against seizures induced by strychnine and picrotoxin. TBM exhibited depressant effect on the central nervous system. After repeated use for 7 days, the PD(50) (MES) of TBM increased to 51.5+/-12.1 mg/kg. Similarly, after repeated use of TBM, the duration of sleep induced by pentobarbital was not reduced significantly. Further studies are required to investigate its usefulness in the treatment of epilepsy.

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          Author and article information

          Journal
          Pharmacology Biochemistry and Behavior
          Pharmacology Biochemistry and Behavior
          Elsevier BV
          00913057
          July 2002
          July 2002
          : 72
          : 4
          : 965-972
          Article
          10.1016/S0091-3057(02)00815-8
          12062587
          5a3db91e-0fc9-4765-b47d-1eb65d1547c2
          © 2002

          https://www.elsevier.com/tdm/userlicense/1.0/

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