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      Reproducibility and Agreement of Anterior Segment Parameter Measurements Obtained Using the CASIA2 and Spectralis OCT2 Optical Coherence Tomography Devices

      , MD, PhD 1 , , MD 1 , , MD 1 , 1 , , MD 1

      Journal of glaucoma

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          Abstract

          Purpose

          To assess the reproducibility and agreement of measurement values obtained from the Tomey CASIA2 and Heidelberg Spectralis OCT2 anterior segment optical coherence tomography (AS-OCT) devices.

          Methods

          Twenty eyes from ten subjects ranging from age 28 to 45 years with no history of eye conditions or intraocular surgery were included. Two scans were obtained with each device in a standardized dark-room environment after a period of dark adaptation. One AS-OCT image along the horizontal (temporal-nasal) meridian was analyzed per eye and per scan. Lens vault (LV), pupil diameter (PD), anterior chamber width (ACW), angle opening distance (AOD), trabecular iris space area (TISA), and scleral spur angle (SSAngle) were measured using manufacturer-provided image analysis programs. Intra-class correlation (ICC) values, coefficients of variation, and Bland-Altman plots were computed to assess the intra-device correlation and inter-device agreement of measurement values.

          Results

          There was excellent intra-device reproducibility of measurement values for both the CASIA (ICC range 0.86 to 0.99) and Spectralis (ICC range 0.79 to 1.00). There was also excellent inter-device correlation of measurement values (ICC range 0.78 to 0.93) for all parameters except ACW (ICC 0.20). Linear regression models and Bland-Altman plots showed that this relationship was strongest when measurement values were small.

          Conclusion

          There is excellent intra-device reproducibility and good inter-device agreement of anterior segment parameter measurement values for the CASIA2 and Spectralis OCT2. However, the measurements obtained with each device should not be considered interchangeable.

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          Author and article information

          Journal
          9300903
          20362
          J Glaucoma
          J. Glaucoma
          Journal of glaucoma
          1057-0829
          1536-481X
          19 September 2017
          November 2017
          01 November 2018
          : 26
          : 11
          : 974-979
          Affiliations
          [1 ]Hamilton Glaucoma Center, Shiley Eye Institute, Department of Ophthalmology, University of California, San Diego, La Jolla, CA
          Author notes
          [# ]to whom correspondence should be addressed: Benjamin Xu, USC Gayle and Edward Roski Eye Institute, Department of Ophthalmology, Keck School of Medicine of the University of Southern California, 1450 San Pablo Street, Suite 4700, Los Angeles, CA 90033, Phone number: 323-442-6780, Fax number: 323-442-6412, benjamin.xu@ 123456med.usc.edu
          Article
          PMC5670007 PMC5670007 5670007 nihpa904968
          10.1097/IJG.0000000000000788
          5670007
          28930883
          Categories
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