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      Rewiring mitochondrial pyruvate metabolism: switching off the light in cancer cells?

      1 , 2 , 3

      Molecular cell

      Elsevier BV

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          Abstract

          Metabolic reprogramming is a characteristic of cancer cells. Three studies published in this month's Molecular Cell provide novel insights into the role of mitochondrial pyruvate in tumor metabolism and describe how targeting pyruvate transport and metabolism may afford therapeutic benefit.

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          Author and article information

          Journal
          Mol. Cell
          Molecular cell
          Elsevier BV
          1097-4164
          1097-2765
          Nov 06 2014
          : 56
          : 3
          Affiliations
          [1 ] Barts Cancer Institute, Queen Mary University of London, Centre for Molecular Oncology, John Vane Science Centre, London EC1M 6BQ, UK. Electronic address: p.w.szlosarek@qmul.ac.uk.
          [2 ] Cancer Biology and Metabolism Group, Institute of Genetics and Molecular Medicine, Edinburgh Cancer Research UK Centre, University of Edinburgh, Western General Hospital, Crewe Road South, Edinburgh EH4 2XR, UK.
          [3 ] Cancer Biology and Metabolism Group, Institute of Genetics and Molecular Medicine, Edinburgh Cancer Research UK Centre, University of Edinburgh, Western General Hospital, Crewe Road South, Edinburgh EH4 2XR, UK. Electronic address: patrickjohnpollard@gmail.com.
          Article
          S1097-2765(14)00828-4
          10.1016/j.molcel.2014.10.018
          25514180

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