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      Confirmation of the absence of tetrodotoxin and its analogues in the juveniles of the Japanese fire-bellied newt, Cynops pyrrhogaster, captive-reared from eggs in the laboratory using HILIC-LC-MS

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      Toxicon

      Elsevier BV

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          Abstract

          The tetrodotoxin (TTX) contents of the Japanese fire-bellied newt, Cynops pyrrhogaster, captive-reared from eggs to metamorphosed juveniles with a non-toxic diet for 70 weeks, as well as wild-caught juvenile newts, were investigated using a high-resolution hydrophilic interaction chromatography-LC-MS. TTX was detected in 0- to 22-week-old captive-reared juvenile newts but was not detected (<15 ng/g) in the 36- to 70-week-old newts, while significant levels of TTX (1.3-14 μg/g) were detected in the wild-caught juveniles.

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          Author and article information

          Journal
          Toxicon
          Toxicon
          Elsevier BV
          00410101
          July 2015
          July 2015
          : 101
          : 101-105
          Article
          10.1016/j.toxicon.2015.05.008
          25986913
          © 2015

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