Blog
About

5
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Philadelphia chromosome-positive acute myeloid leukemia with masses and osteolytic lesions: finding of 18F-FDG PET/CT.

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Philadelphia chromosome-positive acute myeloid leukemia is controversial and difficult to distinguish from the blast phase of chronic myeloid leukemia. As a myeloid neoplasm, rare cases of this leukemia manifest multiple soft-tissue tumors or bone lytic lesions. In this paper, we describe a 49-year-old male patient who had an abrupt onset with sharp chest pain, fever, fatigue, emaciation, and splenomegaly. 18F-fluoro-deoxy-glucose positron emission tomography/computed tomography (18F-FDG PET/CT) result showed diffuse and uneven hypermetabolic lesions in the bone marrow with peripheral bone marrow expansion, multiple soft tissue neoplasms with high 18F-FDG uptake, and lytic bone lesions. Bone marrow smear and biopsy detected aberrant blast cells expressing myeloid rather than lymphoid immunophenotype marker. For the existence of Philadelphia chromosome and BCR-ABL1 fusion gene together with complex chromosome abnormalities, a diagnosis of Philadelphia-positive acute myeloid leukemia was made, although the type (de novo or blast crisis) remained unclear.

          Related collections

          Author and article information

          Journal
          Front Med
          Frontiers of medicine
          Springer Nature
          2095-0225
          2095-0217
          May 27 2017
          Affiliations
          [1 ] Department of Haematology, Qilu Hospital, Shandong University, Jinan, 250012, China.
          [2 ] Department of Haematology, The Affiliated Hospital of Qingdao University, Qingdao, 266000, China.
          [3 ] PET/CT Center, The Affiliated Hospital of Qingdao University, Qingdao, 266000, China.
          [4 ] Department of Hepatobiliary Surgery, The Affiliated Hospital of Qingdao University, Qingdao, 266000, China.
          [5 ] Department of Haematology, Qingdao University Medical College, Qingdao, 266071, China.
          [6 ] Department of Haematology, The Affiliated Hospital of Qingdao University, Qingdao, 266000, China. renjiedi@126.com.
          [7 ] Department of Haematology, Qilu Hospital, Shandong University, Jinan, 250012, China. junpeng88@sina.com.cn.
          Article
          10.1007/s11684-017-0523-x
          10.1007/s11684-017-0523-x
          28550639

          Comments

          Comment on this article