Chronic peripheral joint pain due to osteoarthritis (OA) is extremely prevalent and
a major cause of physical dysfunction and psychosocial distress. Exercise is recommended
to reduce joint pain and improve physical function, but the effect of exercise on
psychosocial function (health beliefs, depression, anxiety and quality of life) in
this population is unknown. To improve our understanding of the complex inter‐relationship
between pain, psychosocial effects, physical function and exercise. Review authors
searched 23 clinical, public health, psychology and social care databases and 25 other
relevant resources including trials registers up to March 2016. We checked reference
lists of included studies for relevant studies. We contacted key experts about unpublished
studies. To be included in the quantitative synthesis, studies had to be randomised
controlled trials of land‐ or water‐based exercise programmes compared with a control
group consisting of no treatment or non‐exercise intervention (such as medication,
patient education) that measured either pain or function and at least one psychosocial
outcome (self‐efficacy, depression, anxiety, quality of life). Participants had to
be aged 45 years or older, with a clinical diagnosis of OA (as defined by the study)
or self‐reported chronic hip or knee (or both) pain (defined as more than six months'
duration). To be included in the qualitative synthesis, studies had to have reported
people's opinions and experiences of exercise‐based programmes (e.g. their views,
understanding, experiences and beliefs about the utility of exercise in the management
of chronic pain/OA). We used standard methodology recommended by Cochrane for the
quantitative analysis. For the qualitative analysis, we extracted verbatim quotes
from study participants and synthesised studies of patients' views using framework
synthesis. We then conducted an integrative review, synthesising the quantitative
and qualitative data together. Twenty‐one trials (2372 participants) met the inclusion
criteria for quantitative synthesis. There were large variations in the exercise programme's
content, mode of delivery, frequency and duration, participant's symptoms, duration
of symptoms, outcomes measured, methodological quality and reporting. Comparator groups
were varied and included normal care; education; and attention controls such as home
visits, sham gel and wait list controls. Risk of bias was high in one and unclear
risk in five studies regarding the randomisation process, high for 11 studies regarding
allocation concealment, high for all 21 studies regarding blinding, and high for three
studies and unclear for five studies regarding attrition. Studies did not provide
information on adverse effects. There was moderate quality evidence that exercise
reduced pain by an absolute percent reduction of 6% (95% confidence interval (CI)
‐9% to ‐4%, (9 studies, 1058 participants), equivalent to reducing (improving) pain
by 1.25 points from 6.5 to 5.3 on a 0 to 20 scale and moderate quality evidence that
exercise improved physical function by an absolute percent of 5.6% (95% CI ‐7.6% to
2.0%; standardised mean difference (SMD) ‐0.27, 95% CI ‐0.37 to ‐0.17, equivalent
to reducing (improving) WOMAC (Western Ontario and McMaster Universities Osteoarthritis
Index) function on a 0 to 100 scale from 49.9 to 44.3) (13 studies, 1599 participants)).
Self‐efficacy was increased by an absolute percent of 1.66% (95% CI 1.08% to 2.20%),
although evidence was low quality (SMD 0.46, 95% CI 0.34 to 0.58, equivalent to improving
the ExBeliefs score on a 17 to 85 scale from 64.3 to 65.4), with small benefits for
depression from moderate quality evidence indicating an absolute percent reduction
of 2.4% (95% CI ‐0.47% to 0.5%) (SMD ‐0.16, 95% CI ‐0.29 to ‐0.02, equivalent to improving
depression measured using HADS (Hospital Anxiety and Depression Scale) on a 0 to 21
scale from 3.5 to 3.0) but no clinically or statistically significant effect on anxiety
(SMD ‐0.11, 95% CI ‐0.26 to 0.05, 2% absolute improvement, 95% CI ‐5% to 1% equivalent
to improving HADS anxiety on a 0 to 21 scale from 5.8 to 5.4; moderate quality evidence).
Five studies measured the effect of exercise on health‐related quality of life using
the 36‐item Short Form (SF‐36) with statistically significant benefits for social
function, increasing it by an absolute percent of 7.9% (95% CI 4.1% to 11.6%), equivalent
to increasing SF‐36 social function on a 0 to 100 scale from 73.6 to 81.5, although
the evidence was low quality. Evidence was downgraded due to heterogeneity of measures,
limitations with blinding and lack of detail regarding interventions. For 20/21 studies,
there was a high risk of bias with blinding as participants self‐reported and were
not blinded to their participation in an exercise intervention. Twelve studies (with
6 to 29 participants) met inclusion criteria for qualitative synthesis. Their methodological
rigour and quality was generally good. From the patients' perspectives, ways to improve
the delivery of exercise interventions included: provide better information and advice
about the safety and value of exercise; provide exercise tailored to individual's
preferences, abilities and needs; challenge inappropriate health beliefs and provide
better support. An integrative review, which compared the findings from quantitative
trials with low risk of bias and the implications derived from the high‐quality studies
in the qualitative synthesis, confirmed the importance of these implications. Chronic
hip and knee pain affects all domains of people's lives. People's beliefs about chronic
pain shape their attitudes and behaviours about how to manage their pain. People are
confused about the cause of their pain, and bewildered by its variability and randomness.
Without adequate information and advice from healthcare professionals, people do not
know what they should and should not do, and, as a consequence, avoid activity for
fear of causing harm. Participation in exercise programmes may slightly improve physical
function, depression and pain. It may slightly improve self‐efficacy and social function,
although there is probably little or no difference in anxiety. Providing reassurance
and clear advice about the value of exercise in controlling symptoms, and opportunities
to participate in exercise programmes that people regard as enjoyable and relevant,
may encourage greater exercise participation, which brings a range of health benefits
to a large population of people. Researchers conducted a review of the effect of exercise
on physical, emotional and mental health for people with long lasting (chronic) knee
or hip joint pain from osteoarthritis. The studies examined were from Europe, North
America, Asia and Australasia, and included clinical settings, home exercise and sessions
at leisure facilities. Studies included men and woman aged 45 years and over. What
is chronic joint pain and what is exercise? Chronic knee and hip pain from osteoarthritis
(breakdown of the bone and cartilage, causing pain and stiffness) is a common cause
of physical disability, anxiety, depression, poor quality of life and social problems
(such as feeling a burden). Exercise is recommended to reduce pain and disability,
and improves people's health beliefs, depression, anxiety and quality of life. We
wanted to improve understanding of the relationships between pain, movement ability,
psychological issues such as depression and anxiety, how chronic pain affects social
relationships, and exercise. What happens to people with chronic knee or hip pain
who take part in exercise programmes? A search of medical databases up to March 2016
found 21 studies with 2372 people which considered pain, movement or both alongside
psychological and social outcomes when people with pain and stiffness in their knee,
hip, or both took part in exercise. Participation in exercise programmes probably
slightly improves pain, physical function, depression, and ability to connect with
others, and little or no difference in anxiety. It may improve belief in one's own
abilities, and social function. The studies confirmed that: ‐ people who exercised
rated their pain to be 1.2 points lower on a scale of 0 to 20 after about 45 weeks
(score: 5.3 with exercise compared with 6.5 with no exercise (control), an improvement
of 6%). ‐ physical function improved by about 5% over 41 weeks (exercise group improved
by 5.6 points on a scale of 0 to 100 (44.3 with exercise compared with 49.9 with control)).
‐ people's confidence in what they could do increased by 2% after 35 weeks (exercise
group improved by 1.1 points on a scale of 17 to 85 (65.4 with exercise compared with
64.3 with control)). ‐ people who exercised were 2% less depressed, or half a point
on a scale of 0 to 21, after 35 weeks (3.0 points with exercise compared with 3.5
with control). ‐ exercise made people feel less anxious about themselves by 2%, a
0.4 drop on a 0 to 21 scale, after 24 weeks (5.4 points with exercise compared with
5.8 with control). ‐ exercise resulted in social interaction improving by 7.9 points
over 36 weeks on a scale of 0 to 100, giving a change of 8% (81.5 with exercise compared
with 73.6 with control). The quality of the evidence was generally moderate, but low
for confidence in ability, mental health and social function. This is mainly due to
varied measures, making comparison more difficult, and because people taking part
knew they were exercising so may have been influenced by expectations of improvement.
The studies did not report side effects. Studies lasted for different durations, so
we do not know if changes occurred quickly and were maintained, or whether improvements
were gradual throughout the studies. Some studies took measurements later after the
programme than others. Additionally, 12 studies investigated people's opinions, beliefs
and experiences of exercise, and whether exercise changed these. The quality of evidence
was high overall. Initially people were confused about the characteristics of their
pain, which shaped their feelings, behaviours and decisions about relieving pain.
People thought movement and exercise was good for joints, but movement caused pain
and they worried this might cause them harm. Lack of information from medical professionals
meant people avoided physical activity and exercise for fear of causing damage. Overall,
people who had taken part in exercise programmes had positive experiences, helping
increase their beliefs that exercise could improve pain, physical and mental health,
and general quality of life. Providing reassurance and exercise advice, challenging
poor health beliefs, and providing enjoyable exercise programmes may encourage participation
and benefit the health of many people.