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      Microtubule attachment and spindle assembly checkpoint signalling at the kinetochore.

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          Abstract

          In eukaryotes, chromosome segregation during cell division is facilitated by the kinetochore, a multiprotein structure that is assembled on centromeric DNA. The kinetochore attaches chromosomes to spindle microtubules, modulates the stability of these attachments and relays the microtubule-binding status to the spindle assembly checkpoint (SAC), a cell cycle surveillance pathway that delays chromosome segregation in response to unattached kinetochores. Recent studies are shaping current thinking on how each of these kinetochore-centred processes is achieved, and how their integration ensures faithful chromosome segregation, focusing on the essential roles of kinase-phosphatase signalling and the microtubule-binding KMN protein network.

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          Author and article information

          Journal
          Nat Rev Mol Cell Biol
          Nature reviews. Molecular cell biology
          Springer Science and Business Media LLC
          1471-0080
          1471-0072
          Jan 2013
          : 14
          : 1
          Affiliations
          [1 ] Cell Biology Program, Sloan-Kettering Institute, 1275 York Ave. New York, New York 10065, USA. foleye1@mskcc.org
          Article
          nrm3494 NIHMS496558
          10.1038/nrm3494
          3762224
          23258294
          5ad50b1c-fb66-44b8-be5c-3e52c612665d
          History

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