-gingerol is one of the main components of ginger with many biological activities. In this study, the effects of ondansetron and -gingerol on pica and gut microbiota in rats injected with cisplatin were evaluated.
Rat model of cisplatin-induced pica was established, and the effects of ondansetron and -gingerol on the gut microbiota were further studied by 16S rDNA gene analysis.
The results showed that the total intake of kaolin of the rats injected with cisplatin was significantly increased, and treatment of ondansetron and -gingerol in advance could significantly ameliorate the pica induced by cisplatin. The body weight of the rats injected with cisplatin was decreased compared with the control group. The 16S rDNA gene analysis has shown that ondansetron, -gingerol and cisplatin could increase the relative abundance of Bacteroidetes and decrease Firmicutes on phylum level.