Review on  D -Allulose:  In vivo  Metabolism, Catalytic Mechanism, Engineering Strain Construction, Bio-Production Technology

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Abstract

Rare sugar D -allulose as a substitute sweetener is produced through the isomerization of D -fructose by D -tagatose 3-epimerases (DTEases) or D -allulose 3-epimerases (DAEases). D -Allulose is a kind of low energy monosaccharide sugar naturally existing in some fruits in very small quantities. D -Allulose not only possesses high value as a food ingredient and dietary supplement, but also exhibits a variety of physiological functions serving as improving insulin resistance, antioxidant enhancement, and hypoglycemic controls, and so forth. Thus, D -allulose has an important development value as an alternative to high-energy sugars. This review provided a systematic analysis of D -allulose characters, application, enzymatic characteristics and molecular modification, engineered strain construction, and processing technologies. The existing problems and its proposed solutions for D -allulose production are also discussed. More importantly, a green and recycling process technology for D -allulose production is proposed for low waste formation, low energy consumption, and high sugar yield.

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Most cited references 84

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Stability of biocatalysts.

Karen M. Polizzi, Andreas Bommarius, James Broering … (2007)

Despite their many favorable qualities, the marginal stability of biocatalysts in many types of reaction media often has prevented or delayed their implementation for industrial-scale synthesis of fine chemicals and pharmaceuticals. Consequently, there is great interest in understanding effects of solution conditions on protein stability, as well as in developing strategies to improve protein stability in desired reaction media. Recent methods include novel chemical modifications of protein, lyophilization in the presence of additives, and physical immobilization on novel supports. Rational and combinatorial protein engineering techniques have been used to yield unmodified proteins with exceptionally improved stability. Both have been aided by the development of computational tools and structure-guided heuristics aimed at reducing library sizes that must be generated and screened to identify improved mutants. The number of parameters used to indicate protein stability can complicate discussions and investigations, and care should be taken to identify whether thermodynamic or kinetic stability limits the observed stability of proteins. Although the useful lifetime of a biocatalyst is dictated by its kinetic stability, only 6% of protein stability studies use kinetic stability measures. Clearly, more effort is needed to study how solution conditions impact protein kinetic stability.

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GLP-1 release and vagal afferent activation mediate the beneficial metabolic and chronotherapeutic effects of D -allulose

Yusaku Iwasaki, Mio Sendo, Katsuya Dezaki … (2018)

Overeating and arrhythmic feeding promote obesity and diabetes. Glucagon-like peptide-1 receptor (GLP-1R) agonists are effective anti-obesity drugs but their use is limited by side effects. Here we show that oral administration of the non-calorie sweetener, rare sugar d-allulose (d-psicose), induces GLP-1 release, activates vagal afferent signaling, reduces food intake and promotes glucose tolerance in healthy and obese-diabetic animal models. Subchronic d-allulose administered at the light period (LP) onset ameliorates LP-specific hyperphagia, visceral obesity, and glucose intolerance. These effects are blunted by vagotomy or pharmacological GLP-1R blockade, and by genetic inactivation of GLP-1R signaling in whole body or selectively in vagal afferents. Our results identify d-allulose as prominent GLP-1 releaser that acts via vagal afferents to restrict feeding and hyperglycemia. Furthermore, when administered in a time-specific manner, chronic d-allulose corrects arrhythmic overeating, obesity and diabetes, suggesting that chronotherapeutic modulation of vagal afferent GLP-1R signaling may aid in treating metabolic disorders.

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Izumoring: a novel and complete strategy for bioproduction of rare sugars.

Ken Izumori, Goro Takata, Masaaki Tokuda … (2003)

Starch, whey or hemicellulosic waste can be used as a raw material for the industrial production of rare sugars. D-glucose from starch, whey and hemicellulose, D-galactose from whey, and D-xylose from hemicellulose are the main starting monosaccharides for production of rare sugars. We can produce all monosaccharides; tetroses, pentoses and hexoses, from these raw materials. This is achieved by using D-tagatose 3-epimerase, aldose isomerase, aldose reductase, and oxidoreductase enzymes or whole cells as biocatalysts. Bioproduction strategies for all rare sugars are illustrated using ring form structures given the name Izumoring.

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Author and article information

Contributors

Peizhou Yang: URI : http://loop.frontiersin.org/people/578712/overview

Journal

Journal ID (nlm-ta): Front Bioeng Biotechnol

Journal ID (iso-abbrev): Front Bioeng Biotechnol

Journal ID (publisher-id): Front. Bioeng. Biotechnol.

Title: Frontiers in Bioengineering and Biotechnology

Publisher: Frontiers Media S.A.

ISSN (Electronic): 2296-4185

Publication date (Electronic): 03 February 2020

Publication date Collection: 2020

Volume: 8

Electronic Location Identifier: 26

Affiliations

[1] ¹Department of Biological, Food and Environment Engineering, Hefei University , Hefei, China

[2] ²Anhui Key Laboratory of Intensive Processing of Agricultural Products, College of Food and Biological Engineering, Hefei University of Technology , Hefei, China

[3] ³Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana–Champaign , Urbana, IL, United States

Author notes

Edited by: Fu-Li Li, Qingdao Institute of Bioenergy and Bioprocess Technology (CAS), China

Reviewed by: Noppol Leksawasdi, Chiang Mai University, Thailand; Hui-Min Qin, Tianjin University of Science and Technology, China; Bo Yu, Institute of Microbiology (CAS), China

*Correspondence: Peizhou Yang, yangpeizhou@ 123456163.com

Guochang Zhang, zgc1984@ 123456illinois.edu

Jingjing Liu, jil263@ 123456illinois.edu

^†These authors have contributed equally to this work and share first authorship

This article was submitted to Bioprocess Engineering, a section of the journal Frontiers in Bioengineering and Biotechnology

Article

DOI: 10.3389/fbioe.2020.00026

PMC ID: 7008614

PubMed ID: 32117915

SO-VID: 5ae42752-e997-48a9-8a26-96a234100d7f

License:

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

History

Date received : 16 October 2019

Date accepted : 13 January 2020

Page count

Figures: 1, Tables: 2, Equations: 0, References: 85, Pages: 10, Words: 0

Funding

Funded by: Natural Science Foundation of Anhui Province 10.13039/501100003995

Award ID: 1908085MC80

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Review on D-Allulose: In vivo Metabolism, Catalytic Mechanism, Engineering Strain Construction, Bio-Production Technology

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