15
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Genetic and cell biological analysis of integrin outside-in signaling.

      Genes & development

      Actins, metabolism, Animals, Cell Physiological Processes, Cytoskeleton, Gene Expression Regulation, Humans, Insulin-Like Growth Factor I, Integrins, genetics, Receptor, IGF Type 1, Signal Transduction, physiology

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Integrins are cell surface transmembrane receptors that recognize and bind to extracellular matrix proteins and counter receptors. Binding of activated integrins to their ligands induces a vast number of structural and signaling changes within the cell. Large, multimolecular complexes assemble onto the cytoplasmic tails of activated integrins to engage and organize the cytoskeleton, and activate signaling pathways that ultimately lead to changes in gene expression. Additionally, integrin-mediated signaling intersects with growth factor-mediated signaling through various levels of cross-talk. This review discusses recent work that has tremendously broadened our understanding of the complexity of integrin-mediated signaling.

          Related collections

          Author and article information

          Journal
          19240129
          10.1101/gad.1758709

          Comments

          Comment on this article