Examination of Pituitary and Ovarian Variables during a 24-Hour Period in Rats after Prolonged Exposure to Continuous Light

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Abstract

Several variables were examined at nine time periods over a 24-hour period in rats following prolonged exposure to constant light (LL), compared with animals housed in an alternating light-dark (LD) environment. The data indicated: LL animals had lower ovarian weights and increased uterine weights, which were not dependent on the time of day of autopsy; pituitary LH content was lower in LL animals, and dependent on time of day only in LD rats; there were no significant differences in serum LH concentrations between the LL and LD animals, nor among times of blood collection; serum FSH concentrations varied significantly with time, but were not different between LL and LD animals. It is suggested that, in the absence of cyclic surges of LH, low tonic levels of serum LH can support estrogen secretion, resulting in higher uterine weight, and that fluctuating but low serum FSH levels may help maintain the follicular stimulation observed in LL animals.

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Journal

Journal ID (publisher-id): NEN

Journal ID (nlm-ta): Neuroendocrinology

Journal ID (doi): 10.1159/issn.0028-3835

Title: Neuroendocrinology

Publisher: S. Karger AG

ISSN (Print): 0028-3835

ISSN (Electronic): 1423-0194

Publication date Subscription-year: 1973

Publication date (Print): 1973

Publication date (Electronic): 25 March 2008

Volume: 13

Issue: 3

Pages: 139-150

Affiliations

Division of Biological Laboratories, Department of Psychiatry, University of Illinois College of Medicine, Chicago

Article

Publisher ID: 122232 Other ID: Neuroendocrinology 1973;13:139–150

DOI: 10.1159/000122232

PubMed ID: 4798414

SO-VID: 5ae7921e-90f0-4411-8210-6b7465e782fb

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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

History

Date received : 01 February 1973

Date accepted : 14 April 1973

Page count

Pages: 12

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