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      Expression of Cytokine Genes in a Patient with Conjunctival Melanoma Compared with Other Pigment Cells

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          Abstract

          Conjunctival melanomas, which have a relatively good prognosis as compared to other mucosal melanomas, have been investigated morphologically and pathologically. We examined the gene expression of several cytokines in a patient with conjunctival melanoma and compared them to those of other pigment cells of the eye, because no reports have discussed cytokine expression in melanoma of the eye. Samples were collected from a 64-year-old woman with conjunctival melanoma and mRNAs were extracted and reverse-transcriptase polymerase chain reaction was performed. We found that potent inhibitors of tumor cell growth such as interleukin 2, 4, 6 and γ-interferon were expressed in the tumor. These inhibitors were not expressed in other pigment cells of the eye, in blood, in conjunctival melanosis or in choroidal melanomas. The basic fibroblast growth factor gene, which has also been known to stimulate melanoma cell growth, was not expressed in the conjunctival melanoma, and it showed +/– or weak expression in choroidal melanomas, but it was expressed in the pigment cells in the eye and in conjunctival melanosis. Although only limited cytokine expression was examined here, these results may suggest an influence of these cytokines to the growth of conjunctival melanoma.

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          Author and article information

          Journal
          ORE
          Ophthalmic Res
          10.1159/issn.0030-3747
          Ophthalmic Research
          S. Karger AG
          0030-3747
          1423-0259
          1998
          August 1998
          12 June 1998
          : 30
          : 4
          : 255-262
          Affiliations
          Department of Ophthalmology, Tohoku University School of Medicine, Sendai, Japan
          Article
          55482 Ophthalmic Res 1998;30:255–262
          10.1159/000055482
          9667056
          5ae9b5e6-df34-4bee-acc3-963947b19bb4
          © 1998 S. Karger AG, Basel

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          History
          Page count
          Figures: 4, References: 26, Pages: 8
          Categories
          Original Paper

          Vision sciences,Ophthalmology & Optometry,Pathology
          Conjunctival melanoma,Interleukin 2,Cytokines,Basic fibroblast growth factor

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