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      Topological Properties and Spatial Organization of Villous Capillaries in Normal and Diabetic Placentas

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          Spatial arrangement and complexity of the capillary bed of placental terminal villi were analyzed in 9 normal and 11 diabetic placentas. Specimens were taken by systematic random sampling, fixed and stained in toto, and embedded in paraffin. Fifteen fields of view were sampled systematically from 120-µm-thick sections of specimens and examined using a confocal laser scanning microscope. Series of thin optical sections of terminal villi and their developmental forms were recorded by the confocal microscope and used as initial data for three-dimensional visualization of the spatial arrangement of villous capillaries. Vascular topology and branching were studied by focusing through the villus, making a schematic drawing of the villous capillary bed and counting redundant capillary connections. It was found that the basic arrangement of villous capillaries is similar in both normal and diabetic placentas. Nevertheless, the proportion of simple forms of the capillary bed without redundant connections is significantly higher in normal placentas and the mean number of redundant connections per villus is significantly higher in diabetic placentas. It is concluded that both the longitudinal growth and branching of capillaries contribute to the increase in the placental capillary bed in late gestation and that the capillary bed of diabetic villi is more complicated due to more intense capillary branching.

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          Increased fetoplacental angiogenesis during first trimester in anaemic women


            Author and article information

            J Vasc Res
            Journal of Vascular Research
            S. Karger AG
            June 2002
            22 August 2008
            : 39
            : 3
            : 268-278
            aInstitute of Histology and Embryology, 1st Faculty of Medicine, Charles University, bInstitute of Physiology, Academy of Sciences, and cDepartment of Obstetrics and Gynecology, General Faculty Hospital and 1st Faculty of Medicine, Charles University, Prague, Czech Republic
            63692 J Vasc Res 2002;39:268–278
            © 2002 S. Karger AG, Basel

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            Page count
            Figures: 13, Tables: 5, References: 42, Pages: 11
            Research Paper


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