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      The mathematical model for total pubertal growth in idiopathic growth hormone (GH) deficiency suggests a moderate role of GH dose.

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          Abstract

          The role of GH treatment during total pubertal growth (TPG) is still unclear. We developed a prediction model for TPG (centimeters) through a multiple regression analysis of various prepubertal parameters in 303 adolescents with idiopathic GH deficiency from the KIGS database. Prepubertal catch-up growth and near-adult height were achieved, and GH dose was kept constant at approximately 30 micro g/kg.d. The model was validated on a cohort of 36 patients from one center. Four TPG predictors explained 70% of the variability with an error SD of 4.2 cm: gender (TPG in males was >11.3 cm vs. that in females), age at onset of puberty (negative), height SD score minus midparental height SD score at puberty onset (negative), and mean GH dose during puberty (positive). Our analysis suggests that TPG in idiopathic GH deficiency is only moderately dependent on GH dose. The use of a higher GH dosage at the onset of puberty should thus depend on the individual's height development. The TPG model aids in the planning of individually optimized and cost-effective GH treatment.

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          Author and article information

          Journal
          J. Clin. Endocrinol. Metab.
          The Journal of clinical endocrinology and metabolism
          The Endocrine Society
          0021-972X
          0021-972X
          Oct 2003
          : 88
          : 10
          Affiliations
          [1 ] Pediatric Endocrinology Section, University Children's Hospital, Tubingen D-72076 Germany. michael.ranke@med.uni-tuebingen.de
          Article
          10.1210/jc.2003-030600
          14557450
          5aee4e9c-ca2f-4790-add9-328bfa7c71a0
          History

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