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Treatment outcomes of patients with multidrug-resistant and extensively drug-resistant tuberculosis according to drug susceptibility testing to first- and second-line drugs: an individual patient data meta-analysis.
Mayara L Bastos ,
Hamidah Hussain ,
Karin Weyer ,
Lourdes Garcia-Garcia ,
Vaira Leimane ,
Chi Chiu Leung ,
Masahiro Narita ,
Jose M Penã ,
Alfredo Ponce-de-Leon ,
Kwonjune J Seung ,
Karen Shean ,
José Sifuentes-Osornio ,
Martie Van der Walt ,
Tjip S Van der Werf ,
Wing Wai Yew ,
Dick Menzies
Nov 15 2014
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Abstract
Individualized treatment for multidrug-resistant (MDR) tuberculosis and extensively drug-resistant (XDR) tuberculosis depends upon reliable and valid drug susceptibility testing (DST) for pyrazinamide, ethambutol, and second-line tuberculosis drugs. However, the reliability of these tests is uncertain, due to unresolved methodological issues. We estimated the association of DST results for pyrazinamide, ethambutol, and second-line drugs with treatment outcomes in patients with MDR tuberculosis and XDR tuberculosis.